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Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations

Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. The efficacy of two lead candidates targeting Pfs25 and Pfs230 antigens to prevent on...

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Autores principales: Bompard, Anais, Da, Dari F., Yerbanga, Rakiswendé S., Biswas, Sumi, Kapulu, Melissa, Bousema, Teun, Lefèvre, Thierry, Cohuet, Anna, Churcher, Thomas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533793/
https://www.ncbi.nlm.nih.gov/pubmed/28754921
http://dx.doi.org/10.1038/s41598-017-06130-1
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author Bompard, Anais
Da, Dari F.
Yerbanga, Rakiswendé S.
Biswas, Sumi
Kapulu, Melissa
Bousema, Teun
Lefèvre, Thierry
Cohuet, Anna
Churcher, Thomas S.
author_facet Bompard, Anais
Da, Dari F.
Yerbanga, Rakiswendé S.
Biswas, Sumi
Kapulu, Melissa
Bousema, Teun
Lefèvre, Thierry
Cohuet, Anna
Churcher, Thomas S.
author_sort Bompard, Anais
collection PubMed
description Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. The efficacy of two lead candidates targeting Pfs25 and Pfs230 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain is assessed using direct membrane feeding assays and murine antibodies in Burkina Faso. The transmission blocking activity of both candidates depends on the level of parasite exposure (as assessed by the mean number of oocysts in control mosquitoes) and antibody titers. A mathematical framework is devised to allow the efficacy of different candidates to be directly compared and determine the minimal antibody titers required to halt transmission in different settings. The increased efficacy with diminishing parasite exposure indicates that the efficacy of vaccines targeting either Pfs25 or Pfs230 may increase as malaria transmission declines. This has important implications for late-stage candidate selection and assessing how they can support the drive for malaria elimination.
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spelling pubmed-55337932017-08-03 Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations Bompard, Anais Da, Dari F. Yerbanga, Rakiswendé S. Biswas, Sumi Kapulu, Melissa Bousema, Teun Lefèvre, Thierry Cohuet, Anna Churcher, Thomas S. Sci Rep Article Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. The efficacy of two lead candidates targeting Pfs25 and Pfs230 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain is assessed using direct membrane feeding assays and murine antibodies in Burkina Faso. The transmission blocking activity of both candidates depends on the level of parasite exposure (as assessed by the mean number of oocysts in control mosquitoes) and antibody titers. A mathematical framework is devised to allow the efficacy of different candidates to be directly compared and determine the minimal antibody titers required to halt transmission in different settings. The increased efficacy with diminishing parasite exposure indicates that the efficacy of vaccines targeting either Pfs25 or Pfs230 may increase as malaria transmission declines. This has important implications for late-stage candidate selection and assessing how they can support the drive for malaria elimination. Nature Publishing Group UK 2017-07-28 /pmc/articles/PMC5533793/ /pubmed/28754921 http://dx.doi.org/10.1038/s41598-017-06130-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Bompard, Anais
Da, Dari F.
Yerbanga, Rakiswendé S.
Biswas, Sumi
Kapulu, Melissa
Bousema, Teun
Lefèvre, Thierry
Cohuet, Anna
Churcher, Thomas S.
Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_full Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_fullStr Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_full_unstemmed Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_short Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_sort evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533793/
https://www.ncbi.nlm.nih.gov/pubmed/28754921
http://dx.doi.org/10.1038/s41598-017-06130-1
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