Bypass of Activation Loop Phosphorylation by Aspartate 836 in Activation of the Endoribonuclease Activity of Ire1

The bifunctional protein kinase-endoribonuclease Ire1 initiates splicing of the mRNA for the transcription factor Hac1 when unfolded proteins accumulate in the endoplasmic reticulum. Activation of Saccharomyces cerevisiae Ire1 coincides with autophosphorylation of its activation loop at S840, S841,...

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Detalles Bibliográficos
Autores principales: Armstrong, Michael C., Šestak, Sergej, Ali, Ahmed A., Sagini, Hanan A. M., Brown, Max, Baty, Karen, Treumann, Achim, Schröder, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533888/
https://www.ncbi.nlm.nih.gov/pubmed/28559428
http://dx.doi.org/10.1128/MCB.00655-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533888/
https://www.ncbi.nlm.nih.gov/pubmed/28559428
http://dx.doi.org/10.1128/MCB.00655-16

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