Cargando…

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

BACKGROUND: One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g. the NMDA-receptor antagonist kynurenic acid (KYNA), has been implicated in long-term cognitive dysfunc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holmberg, Dag, Franzén-Röhl, Elisabeth, Idro, Richard, Opoka, Robert O., Bangirana, Paul, Sellgren, Carl M., Wickström, Ronny, Färnert, Anna, Schwieler, Lilly, Engberg, Göran, John, Chandy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534063/ https://www.ncbi.nlm.nih.gov/pubmed/28754152 http://dx.doi.org/10.1186/s12936-017-1954-1

Ejemplares similares

Sustained Elevation of Kynurenic Acid in the Cerebrospinal Fluid of Patients with Herpes Simplex Virus Type 1 Encephalitis
por: Atlas, Ann, et al.
Publicado: (2013)

Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls
por: Sellgren, Carl M., et al.
Publicado: (2019)

O-08: NEUROCOGNITIVE IMPAIRMENT IN UGANDAN CHILDREN WITH SICKLE CELL ANEMIA COMPARED TO NON-SICKLE SIBLINGS
por: P., BANGIRANA, et al.
Publicado: (2022)

The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis
por: Wickström, Ronny, et al.
Publicado: (2021)

Chronic Antipsychotic Treatment in the Rat – Effects on Brain Interleukin-8 and Kynurenic Acid
por: Larsson, Markus K, et al.
Publicado: (2015)

Socioeconomic Predictors of Cognition in Ugandan Children: Implications for Community Interventions
por: Bangirana, Paul, et al.
Publicado: (2009)

Imbalanced Kynurenine Pathway in Schizophrenia
por: Kegel, Magdalena E, et al.
Publicado: (2014)

Acute kidney injury in Ugandan children with severe malaria is associated with long-term behavioral problems
por: Hickson, Meredith R., et al.
Publicado: (2019)

Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice
por: Peyton, Lee, et al.
Publicado: (2019)

Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria
por: Ouma, Benson J., et al.
Publicado: (2021)

Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria
por: Rivera-Correa, Juan, et al.
Publicado: (2019)

Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
por: Johansson, Viktoria, et al.
Publicado: (2019)

Decreased plasma concentrations of kynurenine and kynurenic acid in schizophrenia patients
por: Markovic, M., et al.
Publicado: (2023)

Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients
por: Schwieler, Lilly, et al.
Publicado: (2016)

Validation of the CogState battery for rapid neurocognitive assessment in Ugandan school age children
por: Bangirana, Paul, et al.
Publicado: (2015)

“I feel so bad but have nothing to do.” Exploring Ugandan caregivers’ experiences of parenting a child with severe malaria and subsequent repeated uncomplicated malaria
por: Nakitende, Ann J., et al.
Publicado: (2018)

The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue
por: Rossi, Franca, et al.
Publicado: (2019)

Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro
por: Sekine, Airi, et al.
Publicado: (2015)

The Metabolic Factor Kynurenic Acid of Kynurenine Pathway Predicts Major Depressive Disorder
por: Liu, Hongye, et al.
Publicado: (2018)

Serum Kynurenic Acid and Kynurenine Are Negatively Associated with the Risk of Adult Moyamoya Disease
por: Yu, Xiaofan, et al.
Publicado: (2022)

Tryptophan, Kynurenine and Kynurenic Acid Concentrations in Milk and Serum of Dairy Cows with Prototheca Mastitis
por: Bochniarz, Mariola, et al.
Publicado: (2021)

Use of the creating opportunities for parent empowerment programme to decrease mental health problems in Ugandan children surviving severe malaria: a randomized controlled trial
por: Bangirana, Paul, et al.
Publicado: (2021)

The Association between Cognition and Academic Performance in Ugandan Children Surviving Malaria with Neurological Involvement
por: Bangirana, Paul, et al.
Publicado: (2013)

Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid
por: Joisten, Niklas, et al.
Publicado: (2020)

Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
por: Saran, Tomasz, et al.
Publicado: (2021)

Elevated Plasma Soluble ST2 Levels are Associated With Neuronal Injury and Neurocognitive Impairment in Children With Cerebral Malaria
por: Fernander, Elizabeth M., et al.
Publicado: (2022)

The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women
por: Quan, Chengxuan, et al.
Publicado: (2020)

Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease
por: Orsatti, Laura, et al.
Publicado: (2021)

Kynurenine, Kynurenic Acid, Quinolinic Acid and Interleukin-6 Levels in the Serum of Patients with Autism Spectrum Disorder
por: Yildirim, Veli, et al.
Publicado: (2023)

Executive function and attention-deficit/hyperactivity disorder in Ugandan children with perinatal HIV exposure
por: Burkey, M. D., et al.
Publicado: (2015)

Malaria with neurological involvement in Ugandan children: effect on cognitive ability, academic achievement and behaviour
por: Bangirana, Paul, et al.
Publicado: (2011)

Vitamin D Insufficiency Is Common in Ugandan Children and Is Associated with Severe Malaria
por: Cusick, Sarah E., et al.
Publicado: (2014)

Association of Plasma Tau With Mortality and Long-term Neurocognitive Impairment in Survivors of Pediatric Cerebral Malaria and Severe Malarial Anemia
por: Datta, Dibyadyuti, et al.
Publicado: (2021)

Nodding syndrome in Ugandan children—clinical features, brain imaging and complications: a case series
por: Idro, Richard, et al.
Publicado: (2013)

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria
por: Conroy, Andrea L., et al.
Publicado: (2019)

Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trial
por: Bangirana, Paul, et al.
Publicado: (2011)

Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae
por: Ohashi, Kazuto, et al.
Publicado: (2017)

Differential Effects of Hypothermia and SZR72 on Cerebral Kynurenine and Kynurenic Acid in a Piglet Model of Hypoxic–Ischemic Encephalopathy
por: Domoki, Ferenc, et al.
Publicado: (2023)

High rate of inappropriate blood transfusions in the management of children with severe anemia in Ugandan hospitals
por: Opoka, Robert O., et al.
Publicado: (2018)

A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
por: Sellgren, CM, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5qv1k55hhsr7lkb7qhrhdtecmr