Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis

Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for an...

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Detalles Bibliográficos
Autores principales: Cantatore, Francesco Paolo, Maruotti, Nicola, Corrado, Addolorata, Ribatti, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534276/
https://www.ncbi.nlm.nih.gov/pubmed/28791304
http://dx.doi.org/10.1155/2017/5345673
Descripción
Sumario:Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosis.

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