Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis

Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for an...

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Detalles Bibliográficos
Autores principales: Cantatore, Francesco Paolo, Maruotti, Nicola, Corrado, Addolorata, Ribatti, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534276/
https://www.ncbi.nlm.nih.gov/pubmed/28791304
http://dx.doi.org/10.1155/2017/5345673
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author Cantatore, Francesco Paolo
Maruotti, Nicola
Corrado, Addolorata
Ribatti, Domenico
author_facet Cantatore, Francesco Paolo
Maruotti, Nicola
Corrado, Addolorata
Ribatti, Domenico
author_sort Cantatore, Francesco Paolo
collection PubMed
description Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosis.
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spelling pubmed-55342762017-08-08 Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis Cantatore, Francesco Paolo Maruotti, Nicola Corrado, Addolorata Ribatti, Domenico Biomed Res Int Review Article Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosis. Hindawi 2017 2017-07-16 /pmc/articles/PMC5534276/ /pubmed/28791304 http://dx.doi.org/10.1155/2017/5345673 Text en Copyright © 2017 Francesco Paolo Cantatore et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cantatore, Francesco Paolo
Maruotti, Nicola
Corrado, Addolorata
Ribatti, Domenico
Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis
title Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis
title_full Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis
title_fullStr Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis
title_full_unstemmed Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis
title_short Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis
title_sort angiogenesis dysregulation in the pathogenesis of systemic sclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534276/
https://www.ncbi.nlm.nih.gov/pubmed/28791304
http://dx.doi.org/10.1155/2017/5345673
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AT ribattidomenico angiogenesisdysregulationinthepathogenesisofsystemicsclerosis

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