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Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by tran...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534284/ https://www.ncbi.nlm.nih.gov/pubmed/28790534 http://dx.doi.org/10.1155/2017/6359871 |
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author | Santiago, Rayra Pereira Vieira, Camilo Adanho, Corynne Stephanie Ahouefa Santana, Sanzio Silva Guarda, Caroline Conceição Figueiredo, Camylla Vilas Boas Fiuza, Luciana Magalhães Pitanga, Thassila Nogueira Ferreira, Junia Raquel Dutra Aleluia, Milena Magalhães Oliveira, Rodrigo Mota Zanette, Dalila Luciola Lyra, Isa Menezes Goncalves, Marilda Souza |
author_facet | Santiago, Rayra Pereira Vieira, Camilo Adanho, Corynne Stephanie Ahouefa Santana, Sanzio Silva Guarda, Caroline Conceição Figueiredo, Camylla Vilas Boas Fiuza, Luciana Magalhães Pitanga, Thassila Nogueira Ferreira, Junia Raquel Dutra Aleluia, Milena Magalhães Oliveira, Rodrigo Mota Zanette, Dalila Luciola Lyra, Isa Menezes Goncalves, Marilda Souza |
author_sort | Santiago, Rayra Pereira |
collection | PubMed |
description | Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children. |
format | Online Article Text |
id | pubmed-5534284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55342842017-08-08 Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease Santiago, Rayra Pereira Vieira, Camilo Adanho, Corynne Stephanie Ahouefa Santana, Sanzio Silva Guarda, Caroline Conceição Figueiredo, Camylla Vilas Boas Fiuza, Luciana Magalhães Pitanga, Thassila Nogueira Ferreira, Junia Raquel Dutra Aleluia, Milena Magalhães Oliveira, Rodrigo Mota Zanette, Dalila Luciola Lyra, Isa Menezes Goncalves, Marilda Souza Dis Markers Research Article Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children. Hindawi 2017 2017-07-16 /pmc/articles/PMC5534284/ /pubmed/28790534 http://dx.doi.org/10.1155/2017/6359871 Text en Copyright © 2017 Rayra Pereira Santiago et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Santiago, Rayra Pereira Vieira, Camilo Adanho, Corynne Stephanie Ahouefa Santana, Sanzio Silva Guarda, Caroline Conceição Figueiredo, Camylla Vilas Boas Fiuza, Luciana Magalhães Pitanga, Thassila Nogueira Ferreira, Junia Raquel Dutra Aleluia, Milena Magalhães Oliveira, Rodrigo Mota Zanette, Dalila Luciola Lyra, Isa Menezes Goncalves, Marilda Souza Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title | Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_full | Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_fullStr | Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_full_unstemmed | Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_short | Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease |
title_sort | laboratory and genetic biomarkers associated with cerebral blood flow velocity in hemoglobin sc disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534284/ https://www.ncbi.nlm.nih.gov/pubmed/28790534 http://dx.doi.org/10.1155/2017/6359871 |
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