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Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease

Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by tran...

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Autores principales: Santiago, Rayra Pereira, Vieira, Camilo, Adanho, Corynne Stephanie Ahouefa, Santana, Sanzio Silva, Guarda, Caroline Conceição, Figueiredo, Camylla Vilas Boas, Fiuza, Luciana Magalhães, Pitanga, Thassila Nogueira, Ferreira, Junia Raquel Dutra, Aleluia, Milena Magalhães, Oliveira, Rodrigo Mota, Zanette, Dalila Luciola, Lyra, Isa Menezes, Goncalves, Marilda Souza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534284/
https://www.ncbi.nlm.nih.gov/pubmed/28790534
http://dx.doi.org/10.1155/2017/6359871
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author Santiago, Rayra Pereira
Vieira, Camilo
Adanho, Corynne Stephanie Ahouefa
Santana, Sanzio Silva
Guarda, Caroline Conceição
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Pitanga, Thassila Nogueira
Ferreira, Junia Raquel Dutra
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota
Zanette, Dalila Luciola
Lyra, Isa Menezes
Goncalves, Marilda Souza
author_facet Santiago, Rayra Pereira
Vieira, Camilo
Adanho, Corynne Stephanie Ahouefa
Santana, Sanzio Silva
Guarda, Caroline Conceição
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Pitanga, Thassila Nogueira
Ferreira, Junia Raquel Dutra
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota
Zanette, Dalila Luciola
Lyra, Isa Menezes
Goncalves, Marilda Souza
author_sort Santiago, Rayra Pereira
collection PubMed
description Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children.
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spelling pubmed-55342842017-08-08 Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease Santiago, Rayra Pereira Vieira, Camilo Adanho, Corynne Stephanie Ahouefa Santana, Sanzio Silva Guarda, Caroline Conceição Figueiredo, Camylla Vilas Boas Fiuza, Luciana Magalhães Pitanga, Thassila Nogueira Ferreira, Junia Raquel Dutra Aleluia, Milena Magalhães Oliveira, Rodrigo Mota Zanette, Dalila Luciola Lyra, Isa Menezes Goncalves, Marilda Souza Dis Markers Research Article Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin. We found that children with TAMMV ≥ 128 cm/s had decreased red blood cell distribution width (RDW) and nitric oxide metabolite (NOx) concentration. Children with TAMMV ≥ 143.50 cm/s had decreased hemoglobin and hematocrit, as well as increased ferritin levels. Decreased hemoglobin, hematocrit, RDW, and NOx and increased ferritin were detected in children with TAMMV ≥ 125.75 cm/s. The CAR haplotype was associated with higher TAMMV. In association analyses, RBC, hemoglobin, hematocrit, RDW, monocyte, DB, NOx, and ferritin, as well as the CAR haplotype, were found to be associated with higher TAMMV in HbSC children. Multivariate analysis suggested that high TAMMV was independently associated with hematocrit, RDW, and NOx. Additional studies are warranted to validate the establishment of a cutoff value of 125.75 cm/s associated with elevated TAMMV in HbSC children. Hindawi 2017 2017-07-16 /pmc/articles/PMC5534284/ /pubmed/28790534 http://dx.doi.org/10.1155/2017/6359871 Text en Copyright © 2017 Rayra Pereira Santiago et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Santiago, Rayra Pereira
Vieira, Camilo
Adanho, Corynne Stephanie Ahouefa
Santana, Sanzio Silva
Guarda, Caroline Conceição
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Pitanga, Thassila Nogueira
Ferreira, Junia Raquel Dutra
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota
Zanette, Dalila Luciola
Lyra, Isa Menezes
Goncalves, Marilda Souza
Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
title Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
title_full Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
title_fullStr Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
title_full_unstemmed Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
title_short Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
title_sort laboratory and genetic biomarkers associated with cerebral blood flow velocity in hemoglobin sc disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534284/
https://www.ncbi.nlm.nih.gov/pubmed/28790534
http://dx.doi.org/10.1155/2017/6359871
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