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Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy

Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases. Increased amounts of urinary protein in DN may be associated with functional and morphological alterations of podocyte, mai...

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Detalles Bibliográficos
Autores principales: Dai, Haoran, Liu, Qingquan, Liu, Baoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534294/
https://www.ncbi.nlm.nih.gov/pubmed/28791309
http://dx.doi.org/10.1155/2017/2615286
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author Dai, Haoran
Liu, Qingquan
Liu, Baoli
author_facet Dai, Haoran
Liu, Qingquan
Liu, Baoli
author_sort Dai, Haoran
collection PubMed
description Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases. Increased amounts of urinary protein in DN may be associated with functional and morphological alterations of podocyte, mainly including podocyte hypertrophy, epithelial-mesenchymal transdifferentiation (EMT), podocyte detachment, and podocyte apoptosis. Accumulating studies have revealed that disruption in multiple renal signaling pathways had been critical in the progression of these pathological damages, such as adenosine monophosphate-activated kinase signaling pathways (AMPK), wnt/β-catenin signaling pathways, endoplasmic reticulum stress-related signaling pathways, mammalian target of rapamycin (mTOR)/autophagy pathway, and Rho GTPases. In this review, we highlight new molecular insights underlying podocyte injury in the progression of DN, which offer new therapeutic targets to develop important renoprotective treatments for DN over the next decade.
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spelling pubmed-55342942017-08-08 Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy Dai, Haoran Liu, Qingquan Liu, Baoli J Diabetes Res Review Article Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases. Increased amounts of urinary protein in DN may be associated with functional and morphological alterations of podocyte, mainly including podocyte hypertrophy, epithelial-mesenchymal transdifferentiation (EMT), podocyte detachment, and podocyte apoptosis. Accumulating studies have revealed that disruption in multiple renal signaling pathways had been critical in the progression of these pathological damages, such as adenosine monophosphate-activated kinase signaling pathways (AMPK), wnt/β-catenin signaling pathways, endoplasmic reticulum stress-related signaling pathways, mammalian target of rapamycin (mTOR)/autophagy pathway, and Rho GTPases. In this review, we highlight new molecular insights underlying podocyte injury in the progression of DN, which offer new therapeutic targets to develop important renoprotective treatments for DN over the next decade. Hindawi 2017 2017-07-16 /pmc/articles/PMC5534294/ /pubmed/28791309 http://dx.doi.org/10.1155/2017/2615286 Text en Copyright © 2017 Haoran Dai et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dai, Haoran
Liu, Qingquan
Liu, Baoli
Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
title Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
title_full Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
title_fullStr Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
title_full_unstemmed Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
title_short Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
title_sort research progress on mechanism of podocyte depletion in diabetic nephropathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534294/
https://www.ncbi.nlm.nih.gov/pubmed/28791309
http://dx.doi.org/10.1155/2017/2615286
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