Emerging molecular targets and therapy for cholangiocarcinoma

Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we...

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Detalles Bibliográficos
Autores principales: Kayhanian, Hamzeh, Smyth, Elizabeth C, Braconi, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534395/
https://www.ncbi.nlm.nih.gov/pubmed/28808500
http://dx.doi.org/10.4251/wjgo.v9.i7.268
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author Kayhanian, Hamzeh
Smyth, Elizabeth C
Braconi, Chiara
author_facet Kayhanian, Hamzeh
Smyth, Elizabeth C
Braconi, Chiara
author_sort Kayhanian, Hamzeh
collection PubMed
description Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for CCA patients.
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spelling pubmed-55343952017-08-14 Emerging molecular targets and therapy for cholangiocarcinoma Kayhanian, Hamzeh Smyth, Elizabeth C Braconi, Chiara World J Gastrointest Oncol Review Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for CCA patients. Baishideng Publishing Group Inc 2017-07-15 2017-07-15 /pmc/articles/PMC5534395/ /pubmed/28808500 http://dx.doi.org/10.4251/wjgo.v9.i7.268 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Review
Kayhanian, Hamzeh
Smyth, Elizabeth C
Braconi, Chiara
Emerging molecular targets and therapy for cholangiocarcinoma
title Emerging molecular targets and therapy for cholangiocarcinoma
title_full Emerging molecular targets and therapy for cholangiocarcinoma
title_fullStr Emerging molecular targets and therapy for cholangiocarcinoma
title_full_unstemmed Emerging molecular targets and therapy for cholangiocarcinoma
title_short Emerging molecular targets and therapy for cholangiocarcinoma
title_sort emerging molecular targets and therapy for cholangiocarcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534395/
https://www.ncbi.nlm.nih.gov/pubmed/28808500
http://dx.doi.org/10.4251/wjgo.v9.i7.268
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