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Use of recombinant human bone morphogenetic protein-2 in spine surgery
Bone morphogenetic proteins are osteoinductive factors which have gained popularity in orthopaedic surgery and especially in spine surgery. The use of recombinant human bone morphogenetic protein-2 has been officially approved by the United States Food and Drug Administration only for single level a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534401/ https://www.ncbi.nlm.nih.gov/pubmed/28808623 http://dx.doi.org/10.5312/wjo.v8.i7.531 |
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author | Lykissas, Marios Gkiatas, Ioannis |
author_facet | Lykissas, Marios Gkiatas, Ioannis |
author_sort | Lykissas, Marios |
collection | PubMed |
description | Bone morphogenetic proteins are osteoinductive factors which have gained popularity in orthopaedic surgery and especially in spine surgery. The use of recombinant human bone morphogenetic protein-2 has been officially approved by the United States Food and Drug Administration only for single level anterior lumbar interbody fusion, nevertheless it is widely used by many surgeons with off-label indications. Despite advantages in bone formation, its use still remains a controversial issue and several complications have been described by authors who oppose their wide use. |
format | Online Article Text |
id | pubmed-5534401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-55344012017-08-14 Use of recombinant human bone morphogenetic protein-2 in spine surgery Lykissas, Marios Gkiatas, Ioannis World J Orthop Minireviews Bone morphogenetic proteins are osteoinductive factors which have gained popularity in orthopaedic surgery and especially in spine surgery. The use of recombinant human bone morphogenetic protein-2 has been officially approved by the United States Food and Drug Administration only for single level anterior lumbar interbody fusion, nevertheless it is widely used by many surgeons with off-label indications. Despite advantages in bone formation, its use still remains a controversial issue and several complications have been described by authors who oppose their wide use. Baishideng Publishing Group Inc 2017-07-18 /pmc/articles/PMC5534401/ /pubmed/28808623 http://dx.doi.org/10.5312/wjo.v8.i7.531 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Minireviews Lykissas, Marios Gkiatas, Ioannis Use of recombinant human bone morphogenetic protein-2 in spine surgery |
title | Use of recombinant human bone morphogenetic protein-2 in spine surgery |
title_full | Use of recombinant human bone morphogenetic protein-2 in spine surgery |
title_fullStr | Use of recombinant human bone morphogenetic protein-2 in spine surgery |
title_full_unstemmed | Use of recombinant human bone morphogenetic protein-2 in spine surgery |
title_short | Use of recombinant human bone morphogenetic protein-2 in spine surgery |
title_sort | use of recombinant human bone morphogenetic protein-2 in spine surgery |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534401/ https://www.ncbi.nlm.nih.gov/pubmed/28808623 http://dx.doi.org/10.5312/wjo.v8.i7.531 |
work_keys_str_mv | AT lykissasmarios useofrecombinanthumanbonemorphogeneticprotein2inspinesurgery AT gkiatasioannis useofrecombinanthumanbonemorphogeneticprotein2inspinesurgery |