Adenosine A(2A) receptor inactivation alleviates early-onset cognitive dysfunction after traumatic brain injury involving an inhibition of tau hyperphosphorylation

Tau is a microtubule-associated protein, and the oligomeric and hyperphosphorylated forms of tau are increased significantly after neurotrauma and considered important factors in mediating cognitive dysfunction. Blockade of adenosine A(2A) receptors, either by caffeine or gene knockout (KO), allevia...

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Detalles Bibliográficos
Autores principales: Zhao, Z-A, Zhao, Y, Ning, Y-L, Yang, N, Peng, Y, Li, P, Chen, X-Y, Liu, D, Wang, H, Chen, X, Bai, W, Chen, J-F, Zhou, Y-G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534966/
https://www.ncbi.nlm.nih.gov/pubmed/28485728
http://dx.doi.org/10.1038/tp.2017.98

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