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Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing

AMP-activated protein kinase (AMPK) is a central cellular energy sensor that adapts metabolism and growth to the energy state of the cell. AMPK senses the ratio of adenine nucleotides (adenylate energy charge) by competitive binding of AMP, ADP, and ATP to three sites (CBS1, CBS3, and CBS4) in its γ...

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Detalles Bibliográficos
Autores principales:	Gu, Xin, Yan, Yan, Novick, Scott J., Kovach, Amanda, Goswami, Devrishi, Ke, Jiyuan, Tan, M. H. Eileen, Wang, Lili, Li, Xiaodan, de Waal, Parker W., Webb, Martin R., Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535039/ https://www.ncbi.nlm.nih.gov/pubmed/28615457 http://dx.doi.org/10.1074/jbc.M117.793018

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