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Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy
Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535226/ https://www.ncbi.nlm.nih.gov/pubmed/28661423 http://dx.doi.org/10.3390/nano7070160 |
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author | Zhu, Zhijun Su, Ming |
author_facet | Zhu, Zhijun Su, Ming |
author_sort | Zhu, Zhijun |
collection | PubMed |
description | Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a carrier to deliver cisplatin via interaction between cisplatin and catechol groups on PDA-NPs. Polyethylene glycol (PEG) was introduced through Michael addition reaction to improve the stability of PDA-NPs in physiological condition. A remarkable synergistic therapeutic effect has been achieved compared with respective single treatments. This work suggests that the PDA-based nanoplatform can be a universal scaffold for combined chemo- and photothermal therapy of cancer. |
format | Online Article Text |
id | pubmed-5535226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55352262017-08-04 Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy Zhu, Zhijun Su, Ming Nanomaterials (Basel) Article Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a carrier to deliver cisplatin via interaction between cisplatin and catechol groups on PDA-NPs. Polyethylene glycol (PEG) was introduced through Michael addition reaction to improve the stability of PDA-NPs in physiological condition. A remarkable synergistic therapeutic effect has been achieved compared with respective single treatments. This work suggests that the PDA-based nanoplatform can be a universal scaffold for combined chemo- and photothermal therapy of cancer. MDPI 2017-06-29 /pmc/articles/PMC5535226/ /pubmed/28661423 http://dx.doi.org/10.3390/nano7070160 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhu, Zhijun Su, Ming Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy |
title | Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy |
title_full | Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy |
title_fullStr | Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy |
title_full_unstemmed | Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy |
title_short | Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy |
title_sort | polydopamine nanoparticles for combined chemo- and photothermal cancer therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535226/ https://www.ncbi.nlm.nih.gov/pubmed/28661423 http://dx.doi.org/10.3390/nano7070160 |
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