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Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy

Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong...

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Detalles Bibliográficos
Autores principales: Zhu, Zhijun, Su, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535226/
https://www.ncbi.nlm.nih.gov/pubmed/28661423
http://dx.doi.org/10.3390/nano7070160
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author Zhu, Zhijun
Su, Ming
author_facet Zhu, Zhijun
Su, Ming
author_sort Zhu, Zhijun
collection PubMed
description Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a carrier to deliver cisplatin via interaction between cisplatin and catechol groups on PDA-NPs. Polyethylene glycol (PEG) was introduced through Michael addition reaction to improve the stability of PDA-NPs in physiological condition. A remarkable synergistic therapeutic effect has been achieved compared with respective single treatments. This work suggests that the PDA-based nanoplatform can be a universal scaffold for combined chemo- and photothermal therapy of cancer.
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spelling pubmed-55352262017-08-04 Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy Zhu, Zhijun Su, Ming Nanomaterials (Basel) Article Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a carrier to deliver cisplatin via interaction between cisplatin and catechol groups on PDA-NPs. Polyethylene glycol (PEG) was introduced through Michael addition reaction to improve the stability of PDA-NPs in physiological condition. A remarkable synergistic therapeutic effect has been achieved compared with respective single treatments. This work suggests that the PDA-based nanoplatform can be a universal scaffold for combined chemo- and photothermal therapy of cancer. MDPI 2017-06-29 /pmc/articles/PMC5535226/ /pubmed/28661423 http://dx.doi.org/10.3390/nano7070160 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhu, Zhijun
Su, Ming
Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy
title Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy
title_full Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy
title_fullStr Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy
title_full_unstemmed Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy
title_short Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy
title_sort polydopamine nanoparticles for combined chemo- and photothermal cancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535226/
https://www.ncbi.nlm.nih.gov/pubmed/28661423
http://dx.doi.org/10.3390/nano7070160
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