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Recent Advances in Magnetic Microfluidic Biosensors

The development of portable biosening devices for the detection of biological entities such as biomolecules, pathogens, and cells has become extremely significant over the past years. Scientific research, driven by the promise for miniaturization and integration of complex laboratory equipment on in...

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Detalles Bibliográficos
Autores principales: Giouroudi, Ioanna, Kokkinis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535237/
https://www.ncbi.nlm.nih.gov/pubmed/28684665
http://dx.doi.org/10.3390/nano7070171
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author Giouroudi, Ioanna
Kokkinis, Georgios
author_facet Giouroudi, Ioanna
Kokkinis, Georgios
author_sort Giouroudi, Ioanna
collection PubMed
description The development of portable biosening devices for the detection of biological entities such as biomolecules, pathogens, and cells has become extremely significant over the past years. Scientific research, driven by the promise for miniaturization and integration of complex laboratory equipment on inexpensive, reliable, and accurate devices, has successfully shifted several analytical and diagnostic methods to the submillimeter scale. The miniaturization process was made possible with the birth of microfluidics, a technology that could confine, manipulate, and mix very small volumes of liquids on devices integrated on standard silicon technology chips. Such devices are then directly translating the presence of these entities into an electronic signal that can be read out with a portable instrumentation. For the aforementioned tasks, the use of magnetic markers (magnetic particles—MPs—functionalized with ligands) in combination with the application of magnetic fields is being strongly investigated by research groups worldwide. The greatest merits of using magnetic fields are that they can be applied either externally or from integrated microconductors and they can be well-tuned by adjusting the applied current on the microconductors. Moreover, the magnetic markers can be manipulated inside microfluidic channels by high gradient magnetic fields that can in turn be detected by magnetic sensors. All the above make this technology an ideal candidate for the development of such microfluidic biosensors. In this review, focus is given only to very recent advances in biosensors that use microfluidics in combination with magnetic sensors and magnetic markers/nanoparticles.
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spelling pubmed-55352372017-08-04 Recent Advances in Magnetic Microfluidic Biosensors Giouroudi, Ioanna Kokkinis, Georgios Nanomaterials (Basel) Review The development of portable biosening devices for the detection of biological entities such as biomolecules, pathogens, and cells has become extremely significant over the past years. Scientific research, driven by the promise for miniaturization and integration of complex laboratory equipment on inexpensive, reliable, and accurate devices, has successfully shifted several analytical and diagnostic methods to the submillimeter scale. The miniaturization process was made possible with the birth of microfluidics, a technology that could confine, manipulate, and mix very small volumes of liquids on devices integrated on standard silicon technology chips. Such devices are then directly translating the presence of these entities into an electronic signal that can be read out with a portable instrumentation. For the aforementioned tasks, the use of magnetic markers (magnetic particles—MPs—functionalized with ligands) in combination with the application of magnetic fields is being strongly investigated by research groups worldwide. The greatest merits of using magnetic fields are that they can be applied either externally or from integrated microconductors and they can be well-tuned by adjusting the applied current on the microconductors. Moreover, the magnetic markers can be manipulated inside microfluidic channels by high gradient magnetic fields that can in turn be detected by magnetic sensors. All the above make this technology an ideal candidate for the development of such microfluidic biosensors. In this review, focus is given only to very recent advances in biosensors that use microfluidics in combination with magnetic sensors and magnetic markers/nanoparticles. MDPI 2017-07-06 /pmc/articles/PMC5535237/ /pubmed/28684665 http://dx.doi.org/10.3390/nano7070171 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giouroudi, Ioanna
Kokkinis, Georgios
Recent Advances in Magnetic Microfluidic Biosensors
title Recent Advances in Magnetic Microfluidic Biosensors
title_full Recent Advances in Magnetic Microfluidic Biosensors
title_fullStr Recent Advances in Magnetic Microfluidic Biosensors
title_full_unstemmed Recent Advances in Magnetic Microfluidic Biosensors
title_short Recent Advances in Magnetic Microfluidic Biosensors
title_sort recent advances in magnetic microfluidic biosensors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535237/
https://www.ncbi.nlm.nih.gov/pubmed/28684665
http://dx.doi.org/10.3390/nano7070171
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