Cargando…
Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane
[Image: see text] We describe the first systematic study of antimalarial 1,2,4-trioxolanes bearing a substitution pattern regioisomeric to that of arterolane. Conformational analysis suggested that trans-3″-substituted trioxolanes would exhibit Fe(II) reactivity and antiparasitic activity similar to...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2017
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535261/ https://www.ncbi.nlm.nih.gov/pubmed/28692297 http://dx.doi.org/10.1021/acs.jmedchem.7b00699 |