Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells

BACKGROUND: The mitogen-activated extracellular signal-regulated kinase 1/2 (MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer (CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations...

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Detalles Bibliográficos
Autores principales: Geng, Rong, Tan, Xin, Zuo, Zhixiang, Wu, Jiangxue, Pan, Zhizhong, Shi, Wei, Liu, Ranyi, Yao, Chen, Wang, Gaoyuan, Lin, Jiaxin, Qiu, Lin, Huang, Wenlin, Chen, Shuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535279/
https://www.ncbi.nlm.nih.gov/pubmed/28756770
http://dx.doi.org/10.1186/s40880-017-0228-1

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