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Pyogenic Granuloma – A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options
Pyogenic granuloma is a common benign vascular tumour occurring in all ages. Both skin and mucous membranes can be affected. Of pathogenetic importance are trauma, BRAF mutations and probably herpes virus type 1, Orf virus and/or human papilloma virus type 2. The tumour consists of capillary prolife...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
ID Design 2012/DOOEL Skopje
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535648/ https://www.ncbi.nlm.nih.gov/pubmed/28785323 http://dx.doi.org/10.3889/oamjms.2017.111 |
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author | Wollina, Uwe Langner, Dana França, Katlein Gianfaldoni, Serena Lotti, Torello Tchernev, Georgi |
author_facet | Wollina, Uwe Langner, Dana França, Katlein Gianfaldoni, Serena Lotti, Torello Tchernev, Georgi |
author_sort | Wollina, Uwe |
collection | PubMed |
description | Pyogenic granuloma is a common benign vascular tumour occurring in all ages. Both skin and mucous membranes can be affected. Of pathogenetic importance are trauma, BRAF mutations and probably herpes virus type 1, Orf virus and/or human papilloma virus type 2. The tumour consists of capillary proliferations, venules and fibromyxoid stroma. The development of a lesion occurs in three stages and bleeding is a common symptom. The tumour can mimic various other vascular lesions, solid tumours, and soft tissue infections. In recent years, targeted tumour therapies have become the most common cause of drug-induced pyogenic granulomas. The backbone of treatment is surgical procedures including laser therapy. New developments in medical drug therapy include topical and systemic beta-adrenergic receptor antagonists timolol and propranolol. Drug therapy is an alternative for young children, ocular and periungual pyogenic granuloma. |
format | Online Article Text |
id | pubmed-5535648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | ID Design 2012/DOOEL Skopje |
record_format | MEDLINE/PubMed |
spelling | pubmed-55356482017-08-07 Pyogenic Granuloma – A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options Wollina, Uwe Langner, Dana França, Katlein Gianfaldoni, Serena Lotti, Torello Tchernev, Georgi Open Access Maced J Med Sci Clinical Science Pyogenic granuloma is a common benign vascular tumour occurring in all ages. Both skin and mucous membranes can be affected. Of pathogenetic importance are trauma, BRAF mutations and probably herpes virus type 1, Orf virus and/or human papilloma virus type 2. The tumour consists of capillary proliferations, venules and fibromyxoid stroma. The development of a lesion occurs in three stages and bleeding is a common symptom. The tumour can mimic various other vascular lesions, solid tumours, and soft tissue infections. In recent years, targeted tumour therapies have become the most common cause of drug-induced pyogenic granulomas. The backbone of treatment is surgical procedures including laser therapy. New developments in medical drug therapy include topical and systemic beta-adrenergic receptor antagonists timolol and propranolol. Drug therapy is an alternative for young children, ocular and periungual pyogenic granuloma. ID Design 2012/DOOEL Skopje 2017-07-13 /pmc/articles/PMC5535648/ /pubmed/28785323 http://dx.doi.org/10.3889/oamjms.2017.111 Text en Copyright: © 2017 Uwe Wollina, Dana Langner, Katlein França, Serena Gianfaldoni, Torello Lotti, Georgi Tchernev. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). |
spellingShingle | Clinical Science Wollina, Uwe Langner, Dana França, Katlein Gianfaldoni, Serena Lotti, Torello Tchernev, Georgi Pyogenic Granuloma – A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options |
title | Pyogenic Granuloma – A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options |
title_full | Pyogenic Granuloma – A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options |
title_fullStr | Pyogenic Granuloma – A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options |
title_full_unstemmed | Pyogenic Granuloma – A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options |
title_short | Pyogenic Granuloma – A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options |
title_sort | pyogenic granuloma – a common benign vascular tumor with variable clinical presentation: new findings and treatment options |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535648/ https://www.ncbi.nlm.nih.gov/pubmed/28785323 http://dx.doi.org/10.3889/oamjms.2017.111 |
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