Associations of Drug Lipophilicity and Extent of Metabolism with Drug-Induced Liver Injury

Drug-induced liver injury (DILI), although rare, is a frequent cause of adverse drug reactions resulting in warnings and withdrawals of numerous medications. Despite the research community’s best efforts, current testing strategies aimed at identifying hepatotoxic drugs prior to human trials are not...

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Detalles Bibliográficos
Autores principales: McEuen, Kristin, Borlak, Jürgen, Tong, Weida, Chen, Minjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535828/
https://www.ncbi.nlm.nih.gov/pubmed/28640208
http://dx.doi.org/10.3390/ijms18071335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535828/
https://www.ncbi.nlm.nih.gov/pubmed/28640208
http://dx.doi.org/10.3390/ijms18071335

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