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Associations of Drug Lipophilicity and Extent of Metabolism with Drug-Induced Liver Injury
Drug-induced liver injury (DILI), although rare, is a frequent cause of adverse drug reactions resulting in warnings and withdrawals of numerous medications. Despite the research community’s best efforts, current testing strategies aimed at identifying hepatotoxic drugs prior to human trials are not...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535828/ https://www.ncbi.nlm.nih.gov/pubmed/28640208 http://dx.doi.org/10.3390/ijms18071335 |