Cargando…

Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway

Capsaicin is a potential chemotherapeutic agent for different human cancers. In Southeast China, nasopharyngeal carcinoma (NPC) has the highest incidence of all cancers, but final treatment outcomes are unsatisfactory. However, there is a lack of information regarding the anticancer activity of caps...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Yu-Tsai, Wang, Hung-Chen, Hsu, Yi-Chiang, Cho, Chung-Lung, Yang, Ming-Yu, Chien, Chih-Yen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535836/ https://www.ncbi.nlm.nih.gov/pubmed/28644386 http://dx.doi.org/10.3390/ijms18071343

Ejemplares similares

Pre-treatment with angiotensin-(1–7) inhibits tumor growth via autophagy by downregulating PI3K/Akt/mTOR signaling in human nasopharyngeal carcinoma xenografts
por: Lin, Yu-Tsai, et al.
Publicado: (2018)

Knockdown of TFRC suppressed the progression of nasopharyngeal carcinoma by downregulating the PI3K/Akt/mTOR pathway
por: Feng, Guofei, et al.
Publicado: (2023)

Silencing c-Jun inhibits autophagy and abrogates radioresistance in nasopharyngeal carcinoma by activating the PI3K/AKT/mTOR pathway
por: Sun, Yongchu, et al.
Publicado: (2021)

Puquitinib mesylate (XC-302) induces autophagy via inhibiting the PI3K/AKT/mTOR signaling pathway in nasopharyngeal cancer cells
por: WANG, KE-FENG, et al.
Publicado: (2015)

Downregulation of PI3K/AKT/mTOR Pathway in Juglone-Treated Bovine Oocytes
por: El-Sheikh, Marwa, et al.
Publicado: (2023)

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma
por: Zhong, Chen, et al.
Publicado: (2019)

ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro
por: Song, Lei, et al.
Publicado: (2020)

ANXA6 Contributes to Radioresistance by Promoting Autophagy via Inhibiting the PI3K/AKT/mTOR Signaling Pathway in Nasopharyngeal Carcinoma
por: Chen, Qianping, et al.
Publicado: (2020)

PI3K/AKT/mTOR Signaling Pathway Is Downregulated by Runzaoling (RZL) in Sjögren's Syndrome
por: Zeng, Ping, et al.
Publicado: (2022)

GSK343 induces autophagy and downregulates the AKT/mTOR signaling pathway in pancreatic cancer cells
por: Xu, Hao, et al.
Publicado: (2019)

Downregulation of AKT/mTOR signaling pathway for Salmonella-mediated autophagy in human anaplastic thyroid cancer
por: Wu, Li-Hsien, et al.
Publicado: (2022)

Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling
por: Tang, Yanghua, et al.
Publicado: (2021)

Calcium Dobesilate Restores Autophagy by Inhibiting the VEGF/PI3K/AKT/mTOR Signaling Pathway
por: Wang, Yue, et al.
Publicado: (2019)

Plac8‐mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway
por: Huang, Mao‐Ling, et al.
Publicado: (2020)

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway
por: Duan, Junchao, et al.
Publicado: (2014)

Capsaicin and sorafenib combination treatment exerts synergistic anti-hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling
por: Dai, Ninggao, et al.
Publicado: (2018)

Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy
por: Wang, Beiyun, et al.
Publicado: (2018)

Dyskerin Downregulation Can Induce ER Stress and Promote Autophagy via AKT-mTOR Signaling Deregulation
por: Maiello, Daniela, et al.
Publicado: (2022)

NPRL2 down‐regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression
por: Wang, Ya‐Chin, et al.
Publicado: (2022)

TEEG Induced A549 Cell Autophagy by Regulating the PI3K/AKT/mTOR Signaling Pathway
por: Shi, Lu, et al.
Publicado: (2019)

Nasopharyngeal carcinoma patient-derived xenograft mouse models reveal potential drugs targeting cell cycle, mTOR, and autophagy pathways
por: Li, Hsin-Pai, et al.
Publicado: (2023)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

Centipeda minima (Ebushicao) extract inhibits PI3K-Akt-mTOR signaling in nasopharyngeal carcinoma CNE-1 cells
por: Guo, Yu-qing, et al.
Publicado: (2015)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells
por: Chang, Huan, et al.
Publicado: (2017)

Activation of Akt/mTOR Pathway Is Associated with Poor Prognosis of Nasopharyngeal Carcinoma
por: Wang, Weiyuan, et al.
Publicado: (2014)

PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer
por: Zhu, Kunrui, et al.
Publicado: (2022)

Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway
por: Hu, Binwu, et al.
Publicado: (2017)

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
por: Cao, Xiongwen, et al.
Publicado: (2021)

Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway
por: ZHAO, ZHONG-QUAN, et al.
Publicado: (2016)

Targeting the PI3K/AKT/mTOR signaling pathway as an effectively radiosensitizing strategy for treating human oral squamous cell carcinoma in vitro and in vivo
por: Yu, Chih-Chia, et al.
Publicado: (2017)

Fluorofenidone attenuates paraquat-induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy
por: Jiang, Feiya, et al.
Publicado: (2021)

Tenacissoside H Induces Autophagy and Radiosensitivity of Hepatocellular Carcinoma Cells by PI3K/Akt/mTOR Signaling Pathway
por: Lin, Jiatian, et al.
Publicado: (2021)

Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition
por: Sun, Zheng, et al.
Publicado: (2018)

Myricetin induces apoptosis and autophagy by inhibiting PI3K/Akt/mTOR signalling in human colon cancer cells
por: Zhu, Ming-liang, et al.
Publicado: (2020)

PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
por: Li, Xiaoman, et al.
Publicado: (2016)

The combination of NVP-BEZ235 and rapamycin regulates nasopharyngeal carcinoma cell viability and apoptosis via the PI3K/AKT/mTOR pathway
por: Luo, Hui, et al.
Publicado: (2019)

Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma
por: Yu, Xiying, et al.
Publicado: (2020)

Sodium cantharidate promotes autophagy in breast cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway
por: Pang, Jin-Long, et al.
Publicado: (2022)

Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells
por: Tsai, Jen-Pi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ohf63dndaq19vg54hcr8aslk63