Allergens with Protease Activity from House Dust Mites

Globally, house dust mites (HDM) are one of the main sources of allergens causing Type I allergy, which has a high risk of progressing into a severe disabling disease manifestation such as allergic asthma. The strong protease activities of a number of these allergens are thought to be involved in se...

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Detalles Bibliográficos
Autores principales: Reithofer, Manuel, Jahn-Schmid, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535861/
https://www.ncbi.nlm.nih.gov/pubmed/28653989
http://dx.doi.org/10.3390/ijms18071368
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author Reithofer, Manuel
Jahn-Schmid, Beatrice
author_facet Reithofer, Manuel
Jahn-Schmid, Beatrice
author_sort Reithofer, Manuel
collection PubMed
description Globally, house dust mites (HDM) are one of the main sources of allergens causing Type I allergy, which has a high risk of progressing into a severe disabling disease manifestation such as allergic asthma. The strong protease activities of a number of these allergens are thought to be involved in several steps of the pathophysiology of this allergic disease. It has been a common notion that protease activity may be one of the properties that confers allergenicity to proteins. In this review we summarize and discuss the roles of the different HDM proteases in the development of Type I allergy.
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spelling pubmed-55358612017-08-04 Allergens with Protease Activity from House Dust Mites Reithofer, Manuel Jahn-Schmid, Beatrice Int J Mol Sci Review Globally, house dust mites (HDM) are one of the main sources of allergens causing Type I allergy, which has a high risk of progressing into a severe disabling disease manifestation such as allergic asthma. The strong protease activities of a number of these allergens are thought to be involved in several steps of the pathophysiology of this allergic disease. It has been a common notion that protease activity may be one of the properties that confers allergenicity to proteins. In this review we summarize and discuss the roles of the different HDM proteases in the development of Type I allergy. MDPI 2017-06-27 /pmc/articles/PMC5535861/ /pubmed/28653989 http://dx.doi.org/10.3390/ijms18071368 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Reithofer, Manuel
Jahn-Schmid, Beatrice
Allergens with Protease Activity from House Dust Mites
title Allergens with Protease Activity from House Dust Mites
title_full Allergens with Protease Activity from House Dust Mites
title_fullStr Allergens with Protease Activity from House Dust Mites
title_full_unstemmed Allergens with Protease Activity from House Dust Mites
title_short Allergens with Protease Activity from House Dust Mites
title_sort allergens with protease activity from house dust mites
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535861/
https://www.ncbi.nlm.nih.gov/pubmed/28653989
http://dx.doi.org/10.3390/ijms18071368
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