The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo

Dysregulated human monocytes/macrophages can synthesize and secrete matrix metalloproteinases (MMPs), which play important roles in the progression of sepsis. In this study, we investigated the effects and mechanism of a novel histone deacetylase (HDAC8) inhibitor, (E)-N-hydroxy-4-methoxy-2-(bipheny...

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Detalles Bibliográficos
Autores principales: Jan, Jing-Shiun, Chou, Yung-Chen, Cheng, Yu-Wen, Chen, Chih-Kuang, Huang, Wei-Jan, Hsiao, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535887/
https://www.ncbi.nlm.nih.gov/pubmed/28661460
http://dx.doi.org/10.3390/ijms18071394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535887/
https://www.ncbi.nlm.nih.gov/pubmed/28661460
http://dx.doi.org/10.3390/ijms18071394

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