Cargando…

Rational Design of Recombinant Papain-Like Cysteine Protease: Optimal Domain Structure and Expression Conditions for Wheat-Derived Enzyme Triticain-α

Triticain-α is a papain-like cysteine protease from wheat (Triticum aestivum L.) that possesses activity towards toxic gluten-derived peptides, and was thus proposed as a novel therapeutic tool for celiac disease. We report an original approach employing rational design of domain architecture of Tri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gorokhovets, Neonila V., Makarov, Vladimir A., Petushkova, Anastasiia I., Prokopets, Olga S., Rubtsov, Mikhail A., Savvateeva, Lyudmila V., Zernii, Evgeni Yu., Zamyatnin, Andrey A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535888/ https://www.ncbi.nlm.nih.gov/pubmed/28661426 http://dx.doi.org/10.3390/ijms18071395

Ejemplares similares

Structure determinants defining the specificity of papain-like cysteine proteases
por: Petushkova, Anastasiia I., et al.
Publicado: (2022)

Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis
por: Soond, Surinder M., et al.
Publicado: (2020)

Papain-Like Proteases as Coronaviral Drug Targets: Current Inhibitors, Opportunities, and Limitations
por: Petushkova, Anastasiia I., et al.
Publicado: (2020)

Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype
por: Rudzińska, Magdalena, et al.
Publicado: (2020)

Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis
por: Soond, Surinder M., et al.
Publicado: (2021)

Redox-Mediated Post-Translational Modifications of Proteolytic Enzymes and Their Role in Protease Functioning
por: Petushkova, Anastasiia I., et al.
Publicado: (2020)

Role of Papain-Like Cysteine Proteases in Plant Development
por: Liu, Huijuan, et al.
Publicado: (2018)

Contact-Dependent Growth Inhibition in Bacteria: Do Not Get Too Close!
por: Ikryannikova, Larisa N., et al.
Publicado: (2020)

Intrinsically Connected: Therapeutically Targeting the Cathepsin Proteases and the Bcl-2 Family of Protein Substrates as Co-regulators of Apoptosis
por: Soond, Surinder M., et al.
Publicado: (2021)

Bacterial Therapy of Cancer: A Way to the Dustbin of History or to the Medicine of the Future?
por: Ikryannikova, Larisa N., et al.
Publicado: (2023)

Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design
por: Frolova, Anastasia S., et al.
Publicado: (2020)

Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy
por: Rudzińska, Magdalena, et al.
Publicado: (2021)

Zinc Modulation of Neuronal Calcium Sensor Proteins: Three Modes of Interaction with Different Structural Outcomes
por: Baksheeva, Viktoriia E., et al.
Publicado: (2022)

Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine
por: Saisawang, Chonticha, et al.
Publicado: (2015)

Papain-like cysteine proteases in Carica papaya: lineage-specific gene duplication and expansion
por: Liu, Juan, et al.
Publicado: (2018)

Molecular modeling and analysis of hepatitis E virus (HEV) papain-like cysteine protease
por: Parvez, Mohammad Khalid, et al.
Publicado: (2014)

A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus
por: Liu, Peng, et al.
Publicado: (2023)

Proteases Underground: Analysis of the Maize Root Apoplast Identifies Organ Specific Papain-Like Cysteine Protease Activity
por: Schulze Hüynck, Jan, et al.
Publicado: (2019)

Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of ‘Papain Superfamily’ Cysteine Proteases
por: Mishra, Manasi, et al.
Publicado: (2020)

Knockout of a papain-like cysteine protease gene OCP enhances blast resistance in rice
por: Li, Yuying, et al.
Publicado: (2022)

Disulfide Dimerization of Neuronal Calcium Sensor-1: Implications for Zinc and Redox Signaling
por: Baksheeva, Viktoriia E., et al.
Publicado: (2021)

Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer
por: Soond, Surinder M., et al.
Publicado: (2019)

Enhancement of Proteolytic Activity of a Thermostable Papain-Like Protease by Structure-Based Rational Design
por: Dutta, Sruti, et al.
Publicado: (2013)

Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting
por: Baldin, Alexey V., et al.
Publicado: (2020)

Identification and classification of papain-like cysteine proteinases
por: Ozhelvaci, Fatih, et al.
Publicado: (2023)

An electrochemical biosensor for SARS-CoV-2 detection via its papain-like cysteine protease and the protease inhibitor screening
por: Liang, Qizhi, et al.
Publicado: (2023)

High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei
por: Alphey, Magnus S., et al.
Publicado: (2006)

Expression, Characterization, and Cellular Localization of Knowpains, Papain-Like Cysteine Proteases of the Plasmodium knowlesi Malaria Parasite
por: Prasad, Rajesh, et al.
Publicado: (2012)

Role of T lymphocytes and papain enzymatic activity in the protection induced by the cysteine protease against Schistosoma mansoni in mice
por: Tallima, Hatem, et al.
Publicado: (2019)

Genome-wide survey of soybean papain-like cysteine proteases and their expression analysis in root nodule symbiosis
por: Yuan, Songli, et al.
Publicado: (2020)

Papain-like cysteine proteases are required for the regulation of photosynthetic gene expression and acclimation to high light stress
por: Alomrani, Sarah, et al.
Publicado: (2021)

Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence
por: Savvateeva, Lyudmila V., et al.
Publicado: (2017)

Genome-wide comparative analysis of papain-like cysteine protease family genes in castor bean and physic nut
por: Zou, Zhi, et al.
Publicado: (2018)

A porcine enterovirus G associated with enteric disease contains a novel papain-like cysteine protease
por: Knutson, Todd P., et al.
Publicado: (2017)

Genome-Wide Identification of Papain-Like Cysteine Proteases in Gossypium hirsutum and Functional Characterization in Response to Verticillium dahliae
por: Zhang, Shuqin, et al.
Publicado: (2019)

Origin and Early Diversification of the Papain Family of Cysteine Peptidases
por: Kordiš, Dušan, et al.
Publicado: (2023)

THE REMOVAL OF CARTILAGE MATRIX, IN VIVO, BY PAPAIN : IDENTIFICATION OF CRYSTALLINE PAPAIN PROTEASE AS THE CAUSE OF THE PHENOMENON
por: McCluskey, Robert T., et al.
Publicado: (1958)

Unfolding Studies of the Cysteine Protease Baupain, a Papain-Like Enzyme from Leaves of Bauhinia forficata: Effect of pH, Guanidine Hydrochloride and Temperature
por: Silva-Lucca, Rosemeire A, et al.
Publicado: (2013)

Papain-Like Cysteine Protease Gene Family in Fig (Ficus carica L.): Genome-Wide Analysis and Expression Patterns
por: Zhai, Yanlei, et al.
Publicado: (2021)

Hepatitis E Virus Cysteine Protease Has Papain Like Properties Validated by in silico Modeling and Cell-Free Inhibition Assays
por: Saraswat, Shweta, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kk72u4b2fc39imb0qmdpkoenl3