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Immunological and Inflammatory Impact of Non-Intubated Lung Metastasectomy
Background: We hypothesized that video-assisted thoracic surgery (VATS) lung metastasectomy under non-intubated anesthesia may have a lesser immunological and inflammatory impact than the same procedure under general anesthesia. Methods: Between December 2005 and October 2015, 55 patients with pulmo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535957/ https://www.ncbi.nlm.nih.gov/pubmed/28686211 http://dx.doi.org/10.3390/ijms18071466 |
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author | Mineo, Tommaso Claudio Sellitri, Francesco Vanni, Gianluca Gallina, Filippo Tommaso Ambrogi, Vincenzo |
author_facet | Mineo, Tommaso Claudio Sellitri, Francesco Vanni, Gianluca Gallina, Filippo Tommaso Ambrogi, Vincenzo |
author_sort | Mineo, Tommaso Claudio |
collection | PubMed |
description | Background: We hypothesized that video-assisted thoracic surgery (VATS) lung metastasectomy under non-intubated anesthesia may have a lesser immunological and inflammatory impact than the same procedure under general anesthesia. Methods: Between December 2005 and October 2015, 55 patients with pulmonary oligometastases (at the first episode) successfully underwent VATS metastasectomy under non-intubated anesthesia. Lymphocytes subpopulation and interleukins 6 and 10 were measured at different intervals and matched with a control group composed of 13 patients with similar clinical features who refused non-intubated surgery. Results: The non-intubated group demonstrated a lesser reduction of natural killer lymphocytes at 7 days from the procedure (p = 0.04) compared to control. Furthermore, the group revealed a lesser spillage of interleukin 6 after 1 (p = 0.03), 7 (p = 0.04), and 14 (p = 0.05) days. There was no mortality in any groups. Major morbidity rate was significantly higher in the general anesthesia group 3 (5%) vs. 3 (23%) (p = 0.04). The median hospital stay was 3.0 vs. 3.7 (p = 0.033) days, the estimated costs with the non-intubated procedure was significantly lower, even excluding the hospital stay. Conclusions: VATS lung metastasectomy in non-intubated anesthesia had significantly lesser impact on both immunological and inflammatory response compared to traditional procedure in intubated general anesthesia. |
format | Online Article Text |
id | pubmed-5535957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55359572017-08-04 Immunological and Inflammatory Impact of Non-Intubated Lung Metastasectomy Mineo, Tommaso Claudio Sellitri, Francesco Vanni, Gianluca Gallina, Filippo Tommaso Ambrogi, Vincenzo Int J Mol Sci Article Background: We hypothesized that video-assisted thoracic surgery (VATS) lung metastasectomy under non-intubated anesthesia may have a lesser immunological and inflammatory impact than the same procedure under general anesthesia. Methods: Between December 2005 and October 2015, 55 patients with pulmonary oligometastases (at the first episode) successfully underwent VATS metastasectomy under non-intubated anesthesia. Lymphocytes subpopulation and interleukins 6 and 10 were measured at different intervals and matched with a control group composed of 13 patients with similar clinical features who refused non-intubated surgery. Results: The non-intubated group demonstrated a lesser reduction of natural killer lymphocytes at 7 days from the procedure (p = 0.04) compared to control. Furthermore, the group revealed a lesser spillage of interleukin 6 after 1 (p = 0.03), 7 (p = 0.04), and 14 (p = 0.05) days. There was no mortality in any groups. Major morbidity rate was significantly higher in the general anesthesia group 3 (5%) vs. 3 (23%) (p = 0.04). The median hospital stay was 3.0 vs. 3.7 (p = 0.033) days, the estimated costs with the non-intubated procedure was significantly lower, even excluding the hospital stay. Conclusions: VATS lung metastasectomy in non-intubated anesthesia had significantly lesser impact on both immunological and inflammatory response compared to traditional procedure in intubated general anesthesia. MDPI 2017-07-07 /pmc/articles/PMC5535957/ /pubmed/28686211 http://dx.doi.org/10.3390/ijms18071466 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mineo, Tommaso Claudio Sellitri, Francesco Vanni, Gianluca Gallina, Filippo Tommaso Ambrogi, Vincenzo Immunological and Inflammatory Impact of Non-Intubated Lung Metastasectomy |
title | Immunological and Inflammatory Impact of Non-Intubated Lung Metastasectomy |
title_full | Immunological and Inflammatory Impact of Non-Intubated Lung Metastasectomy |
title_fullStr | Immunological and Inflammatory Impact of Non-Intubated Lung Metastasectomy |
title_full_unstemmed | Immunological and Inflammatory Impact of Non-Intubated Lung Metastasectomy |
title_short | Immunological and Inflammatory Impact of Non-Intubated Lung Metastasectomy |
title_sort | immunological and inflammatory impact of non-intubated lung metastasectomy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535957/ https://www.ncbi.nlm.nih.gov/pubmed/28686211 http://dx.doi.org/10.3390/ijms18071466 |
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