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Ubiquitination in Periodontal Disease: A Review

Periodontal disease (periodontitis) is a chronic inflammatory condition initiated by microbial infection that leads to gingival tissue destruction and alveolar bone resorption. The periodontal tissue’s response to dental plaque is characterized by the accumulation of polymorphonuclear leukocytes, ma...

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Detalles Bibliográficos
Autores principales: Tsuchida, Sachio, Satoh, Mamoru, Takiwaki, Masaki, Nomura, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535967/
https://www.ncbi.nlm.nih.gov/pubmed/28698506
http://dx.doi.org/10.3390/ijms18071476
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author Tsuchida, Sachio
Satoh, Mamoru
Takiwaki, Masaki
Nomura, Fumio
author_facet Tsuchida, Sachio
Satoh, Mamoru
Takiwaki, Masaki
Nomura, Fumio
author_sort Tsuchida, Sachio
collection PubMed
description Periodontal disease (periodontitis) is a chronic inflammatory condition initiated by microbial infection that leads to gingival tissue destruction and alveolar bone resorption. The periodontal tissue’s response to dental plaque is characterized by the accumulation of polymorphonuclear leukocytes, macrophages, and lymphocytes, all of which release inflammatory mediators and cytokines to orchestrate the immunopathogenesis of periodontal disease. Ubiquitination is achieved by a mechanism that involves a number of factors, including an ubiquitin-activating enzyme, ubiquitin-conjugating enzyme, and ubiquitin–protein ligase. Ubiquitination is a post-translational modification restricted to eukaryotes that are involved in essential host processes. The ubiquitin system has been implicated in the immune response, development, and programmed cell death. Increasing numbers of recent reports have provided evidence that many approaches are delivering promising reports for discovering the relationship between ubiquitination and periodontal disease. The scope of this review was to investigate recent progress in the discovery of ubiquitinated protein in diseased periodontium and to discuss the ubiquitination process in periodontal diseases.
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spelling pubmed-55359672017-08-04 Ubiquitination in Periodontal Disease: A Review Tsuchida, Sachio Satoh, Mamoru Takiwaki, Masaki Nomura, Fumio Int J Mol Sci Review Periodontal disease (periodontitis) is a chronic inflammatory condition initiated by microbial infection that leads to gingival tissue destruction and alveolar bone resorption. The periodontal tissue’s response to dental plaque is characterized by the accumulation of polymorphonuclear leukocytes, macrophages, and lymphocytes, all of which release inflammatory mediators and cytokines to orchestrate the immunopathogenesis of periodontal disease. Ubiquitination is achieved by a mechanism that involves a number of factors, including an ubiquitin-activating enzyme, ubiquitin-conjugating enzyme, and ubiquitin–protein ligase. Ubiquitination is a post-translational modification restricted to eukaryotes that are involved in essential host processes. The ubiquitin system has been implicated in the immune response, development, and programmed cell death. Increasing numbers of recent reports have provided evidence that many approaches are delivering promising reports for discovering the relationship between ubiquitination and periodontal disease. The scope of this review was to investigate recent progress in the discovery of ubiquitinated protein in diseased periodontium and to discuss the ubiquitination process in periodontal diseases. MDPI 2017-07-10 /pmc/articles/PMC5535967/ /pubmed/28698506 http://dx.doi.org/10.3390/ijms18071476 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tsuchida, Sachio
Satoh, Mamoru
Takiwaki, Masaki
Nomura, Fumio
Ubiquitination in Periodontal Disease: A Review
title Ubiquitination in Periodontal Disease: A Review
title_full Ubiquitination in Periodontal Disease: A Review
title_fullStr Ubiquitination in Periodontal Disease: A Review
title_full_unstemmed Ubiquitination in Periodontal Disease: A Review
title_short Ubiquitination in Periodontal Disease: A Review
title_sort ubiquitination in periodontal disease: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535967/
https://www.ncbi.nlm.nih.gov/pubmed/28698506
http://dx.doi.org/10.3390/ijms18071476
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