miRNAs in Normal and Malignant Hematopoiesis

Lineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs) are 18–24 nucleotide-long non-coding RNAs that post-transcriptionally decrease the translation of target mRNAs and are essential for many cell...

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Detalles Bibliográficos
Autores principales: Kotaki, Ryutaro, Koyama-Nasu, Ryo, Yamakawa, Natsuko, Kotani, Ai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535985/
https://www.ncbi.nlm.nih.gov/pubmed/28696359
http://dx.doi.org/10.3390/ijms18071495
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author Kotaki, Ryutaro
Koyama-Nasu, Ryo
Yamakawa, Natsuko
Kotani, Ai
author_facet Kotaki, Ryutaro
Koyama-Nasu, Ryo
Yamakawa, Natsuko
Kotani, Ai
author_sort Kotaki, Ryutaro
collection PubMed
description Lineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs) are 18–24 nucleotide-long non-coding RNAs that post-transcriptionally decrease the translation of target mRNAs and are essential for many cellular functions. miRNAs also regulate lineage specification during hematopoiesis. This review highlights the roles of miRNAs in B-cell development and malignancies, and discusses how miRNA expression profiles correlate with disease prognoses and phenotypes. We also discuss the potential for miRNAs as therapeutic targets and diagnostic tools for B-cell malignancies.
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spelling pubmed-55359852017-08-04 miRNAs in Normal and Malignant Hematopoiesis Kotaki, Ryutaro Koyama-Nasu, Ryo Yamakawa, Natsuko Kotani, Ai Int J Mol Sci Review Lineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs) are 18–24 nucleotide-long non-coding RNAs that post-transcriptionally decrease the translation of target mRNAs and are essential for many cellular functions. miRNAs also regulate lineage specification during hematopoiesis. This review highlights the roles of miRNAs in B-cell development and malignancies, and discusses how miRNA expression profiles correlate with disease prognoses and phenotypes. We also discuss the potential for miRNAs as therapeutic targets and diagnostic tools for B-cell malignancies. MDPI 2017-07-11 /pmc/articles/PMC5535985/ /pubmed/28696359 http://dx.doi.org/10.3390/ijms18071495 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kotaki, Ryutaro
Koyama-Nasu, Ryo
Yamakawa, Natsuko
Kotani, Ai
miRNAs in Normal and Malignant Hematopoiesis
title miRNAs in Normal and Malignant Hematopoiesis
title_full miRNAs in Normal and Malignant Hematopoiesis
title_fullStr miRNAs in Normal and Malignant Hematopoiesis
title_full_unstemmed miRNAs in Normal and Malignant Hematopoiesis
title_short miRNAs in Normal and Malignant Hematopoiesis
title_sort mirnas in normal and malignant hematopoiesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535985/
https://www.ncbi.nlm.nih.gov/pubmed/28696359
http://dx.doi.org/10.3390/ijms18071495
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AT yamakawanatsuko mirnasinnormalandmalignanthematopoiesis
AT kotaniai mirnasinnormalandmalignanthematopoiesis

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