The Role of Ghrelin and Ghrelin Signaling in Aging

With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigeni...

Descripción completa

Detalles Bibliográficos
Autores principales: Amitani, Marie, Amitani, Haruka, Cheng, Kai-Chun, Kairupan, Timothy Sean, Sameshima, Nanami, Shimoshikiryo, Ippei, Mizuma, Kimiko, Rokot, Natasya Trivena, Nerome, Yasuhito, Owaki, Tetsuhiro, Asakawa, Akihiro, Inui, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536001/
https://www.ncbi.nlm.nih.gov/pubmed/28704966
http://dx.doi.org/10.3390/ijms18071511
Descripción
Sumario:With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide. Because ghrelin is increased by caloric restriction, ghrelin may play an important role in the mechanism of longevity mediated by calorie restriction. In this review, we will discuss the role of orexigenic peptides with a particular focus on ghrelin. We conclude that the ghrelin-growth hormone secretagogue-R signaling pathway may play an important role in the anti-aging mechanism.

Ejemplares similares