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Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer
The onset and selection of resistant clones during cancer treatment with chemotherapy or targeted therapy is a major issue in the clinical management of metastatic colorectal cancer patients. It is possible that a more personalized treatment selection, using reliable response-to-therapy predictive b...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536035/ https://www.ncbi.nlm.nih.gov/pubmed/28714940 http://dx.doi.org/10.3390/ijms18071547 |
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author | Garajová, Ingrid Ferracin, Manuela Porcellini, Elisa Palloni, Andrea Abbati, Francesca Biasco, Guido Brandi, Giovanni |
author_facet | Garajová, Ingrid Ferracin, Manuela Porcellini, Elisa Palloni, Andrea Abbati, Francesca Biasco, Guido Brandi, Giovanni |
author_sort | Garajová, Ingrid |
collection | PubMed |
description | The onset and selection of resistant clones during cancer treatment with chemotherapy or targeted therapy is a major issue in the clinical management of metastatic colorectal cancer patients. It is possible that a more personalized treatment selection, using reliable response-to-therapy predictive biomarkers, could lead to an improvement in the success rate of the proposed therapies. Although the process of biomarker selection and validation could be a long one, requiring solid statistics, large cohorts and multicentric validations, non-coding RNAs (ncRNAs) and in particular microRNAs, proved to be extremely promising in this field. Here we summarize some of the main studies correlating specific ncRNAs with sensitivity/resistance to chemotherapy, anti-VEGF therapy, anti-EGFR therapy and immunotherapy in colorectal cancer (CRC). |
format | Online Article Text |
id | pubmed-5536035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55360352017-08-04 Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer Garajová, Ingrid Ferracin, Manuela Porcellini, Elisa Palloni, Andrea Abbati, Francesca Biasco, Guido Brandi, Giovanni Int J Mol Sci Review The onset and selection of resistant clones during cancer treatment with chemotherapy or targeted therapy is a major issue in the clinical management of metastatic colorectal cancer patients. It is possible that a more personalized treatment selection, using reliable response-to-therapy predictive biomarkers, could lead to an improvement in the success rate of the proposed therapies. Although the process of biomarker selection and validation could be a long one, requiring solid statistics, large cohorts and multicentric validations, non-coding RNAs (ncRNAs) and in particular microRNAs, proved to be extremely promising in this field. Here we summarize some of the main studies correlating specific ncRNAs with sensitivity/resistance to chemotherapy, anti-VEGF therapy, anti-EGFR therapy and immunotherapy in colorectal cancer (CRC). MDPI 2017-07-17 /pmc/articles/PMC5536035/ /pubmed/28714940 http://dx.doi.org/10.3390/ijms18071547 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Garajová, Ingrid Ferracin, Manuela Porcellini, Elisa Palloni, Andrea Abbati, Francesca Biasco, Guido Brandi, Giovanni Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer |
title | Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer |
title_full | Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer |
title_fullStr | Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer |
title_full_unstemmed | Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer |
title_short | Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer |
title_sort | non-coding rnas as predictive biomarkers to current treatment in metastatic colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536035/ https://www.ncbi.nlm.nih.gov/pubmed/28714940 http://dx.doi.org/10.3390/ijms18071547 |
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