Cargando…

Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis

Studies evaluating the effects of high-saturated fat diets on cardiac function are most often confounded by diet-induced obesity and by systemic insulin resistance. We evaluated whether coconut oil, containing C12:0 and C14:0 as main fatty acids, aggravates pressure overload-induced cardiomyopathy i...

Descripción completa

Detalles Bibliográficos
Autores principales: Muthuramu, Ilayaraja, Amin, Ruhul, Postnov, Andrey, Mishra, Mudit, Jacobs, Frank, Gheysens, Olivier, Van Veldhoven, Paul P., De Geest, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536053/
https://www.ncbi.nlm.nih.gov/pubmed/28718833
http://dx.doi.org/10.3390/ijms18071565
_version_ 1783253956274683904
author Muthuramu, Ilayaraja
Amin, Ruhul
Postnov, Andrey
Mishra, Mudit
Jacobs, Frank
Gheysens, Olivier
Van Veldhoven, Paul P.
De Geest, Bart
author_facet Muthuramu, Ilayaraja
Amin, Ruhul
Postnov, Andrey
Mishra, Mudit
Jacobs, Frank
Gheysens, Olivier
Van Veldhoven, Paul P.
De Geest, Bart
author_sort Muthuramu, Ilayaraja
collection PubMed
description Studies evaluating the effects of high-saturated fat diets on cardiac function are most often confounded by diet-induced obesity and by systemic insulin resistance. We evaluated whether coconut oil, containing C12:0 and C14:0 as main fatty acids, aggravates pressure overload-induced cardiomyopathy induced by transverse aortic constriction (TAC) in C57BL/6 mice. Mortality rate after TAC was higher (p < 0.05) in 0.2% cholesterol 10% coconut oil diet-fed mice than in standard chow-fed mice (hazard ratio 2.32, 95% confidence interval 1.16 to 4.64) during eight weeks of follow-up. The effects of coconut oil on cardiac remodeling occurred in the absence of weight gain and of systemic insulin resistance. Wet lung weight was 1.76-fold (p < 0.01) higher in coconut oil mice than in standard chow mice. Myocardial capillary density (p < 0.001) was decreased, interstitial fibrosis was 1.88-fold (p < 0.001) higher, and systolic and diastolic function was worse in coconut oil mice than in standard chow mice. Myocardial glucose uptake was 1.86-fold (p < 0.001) higher in coconut oil mice and was accompanied by higher myocardial pyruvate dehydrogenase levels and higher acetyl-CoA carboxylase levels. The coconut oil diet increased oxidative stress. Myocardial triglycerides and free fatty acids were lower (p < 0.05) in coconut oil mice. In conclusion, coconut oil aggravates pressure overload-induced cardiomyopathy.
format Online
Article
Text
id pubmed-5536053
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-55360532017-08-04 Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis Muthuramu, Ilayaraja Amin, Ruhul Postnov, Andrey Mishra, Mudit Jacobs, Frank Gheysens, Olivier Van Veldhoven, Paul P. De Geest, Bart Int J Mol Sci Article Studies evaluating the effects of high-saturated fat diets on cardiac function are most often confounded by diet-induced obesity and by systemic insulin resistance. We evaluated whether coconut oil, containing C12:0 and C14:0 as main fatty acids, aggravates pressure overload-induced cardiomyopathy induced by transverse aortic constriction (TAC) in C57BL/6 mice. Mortality rate after TAC was higher (p < 0.05) in 0.2% cholesterol 10% coconut oil diet-fed mice than in standard chow-fed mice (hazard ratio 2.32, 95% confidence interval 1.16 to 4.64) during eight weeks of follow-up. The effects of coconut oil on cardiac remodeling occurred in the absence of weight gain and of systemic insulin resistance. Wet lung weight was 1.76-fold (p < 0.01) higher in coconut oil mice than in standard chow mice. Myocardial capillary density (p < 0.001) was decreased, interstitial fibrosis was 1.88-fold (p < 0.001) higher, and systolic and diastolic function was worse in coconut oil mice than in standard chow mice. Myocardial glucose uptake was 1.86-fold (p < 0.001) higher in coconut oil mice and was accompanied by higher myocardial pyruvate dehydrogenase levels and higher acetyl-CoA carboxylase levels. The coconut oil diet increased oxidative stress. Myocardial triglycerides and free fatty acids were lower (p < 0.05) in coconut oil mice. In conclusion, coconut oil aggravates pressure overload-induced cardiomyopathy. MDPI 2017-07-18 /pmc/articles/PMC5536053/ /pubmed/28718833 http://dx.doi.org/10.3390/ijms18071565 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Muthuramu, Ilayaraja
Amin, Ruhul
Postnov, Andrey
Mishra, Mudit
Jacobs, Frank
Gheysens, Olivier
Van Veldhoven, Paul P.
De Geest, Bart
Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis
title Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis
title_full Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis
title_fullStr Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis
title_full_unstemmed Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis
title_short Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis
title_sort coconut oil aggravates pressure overload-induced cardiomyopathy without inducing obesity, systemic insulin resistance, or cardiac steatosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536053/
https://www.ncbi.nlm.nih.gov/pubmed/28718833
http://dx.doi.org/10.3390/ijms18071565
work_keys_str_mv AT muthuramuilayaraja coconutoilaggravatespressureoverloadinducedcardiomyopathywithoutinducingobesitysystemicinsulinresistanceorcardiacsteatosis
AT aminruhul coconutoilaggravatespressureoverloadinducedcardiomyopathywithoutinducingobesitysystemicinsulinresistanceorcardiacsteatosis
AT postnovandrey coconutoilaggravatespressureoverloadinducedcardiomyopathywithoutinducingobesitysystemicinsulinresistanceorcardiacsteatosis
AT mishramudit coconutoilaggravatespressureoverloadinducedcardiomyopathywithoutinducingobesitysystemicinsulinresistanceorcardiacsteatosis
AT jacobsfrank coconutoilaggravatespressureoverloadinducedcardiomyopathywithoutinducingobesitysystemicinsulinresistanceorcardiacsteatosis
AT gheysensolivier coconutoilaggravatespressureoverloadinducedcardiomyopathywithoutinducingobesitysystemicinsulinresistanceorcardiacsteatosis
AT vanveldhovenpaulp coconutoilaggravatespressureoverloadinducedcardiomyopathywithoutinducingobesitysystemicinsulinresistanceorcardiacsteatosis
AT degeestbart coconutoilaggravatespressureoverloadinducedcardiomyopathywithoutinducingobesitysystemicinsulinresistanceorcardiacsteatosis