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New Insights into the Role of Autophagy in Tumor Immune Microenvironment

The tumor microenvironment is a complex system that is affected by various factors, including hypoxia, acidosis, and immune and inflammatory responses, which have significant effects on tumor adhesion, invasion, metastasis, angiogenesis, and autophagy. In this hostile tumor microenvironment, autopha...

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Detalles Bibliográficos
Autores principales: Li, Chia-Jung, Liao, Wan-Ting, Wu, Meng-Yu, Chu, Pei-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536054/
https://www.ncbi.nlm.nih.gov/pubmed/28753959
http://dx.doi.org/10.3390/ijms18071566
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author Li, Chia-Jung
Liao, Wan-Ting
Wu, Meng-Yu
Chu, Pei-Yi
author_facet Li, Chia-Jung
Liao, Wan-Ting
Wu, Meng-Yu
Chu, Pei-Yi
author_sort Li, Chia-Jung
collection PubMed
description The tumor microenvironment is a complex system that is affected by various factors, including hypoxia, acidosis, and immune and inflammatory responses, which have significant effects on tumor adhesion, invasion, metastasis, angiogenesis, and autophagy. In this hostile tumor microenvironment, autophagy of tumor cells can promote tumor growth and metastasis. As autophagy is a double-edged sword in tumors, treatment of cancer via regulation of autophagy is extremely complicated. Therefore, understanding the relationship between tumor autophagy and the tumor microenvironment is extremely important. As the immune milieu plays an important role in tumor development, immunotherapy has become a promising form of cancer therapy. A multi-pronged treatment approach using immunotherapy and molecular targets may become the major direction for future cancer treatments. This article reviews existing knowledge regarding the immune factors in the tumor microenvironment and the status of tumor autophagy research.
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spelling pubmed-55360542017-08-04 New Insights into the Role of Autophagy in Tumor Immune Microenvironment Li, Chia-Jung Liao, Wan-Ting Wu, Meng-Yu Chu, Pei-Yi Int J Mol Sci Review The tumor microenvironment is a complex system that is affected by various factors, including hypoxia, acidosis, and immune and inflammatory responses, which have significant effects on tumor adhesion, invasion, metastasis, angiogenesis, and autophagy. In this hostile tumor microenvironment, autophagy of tumor cells can promote tumor growth and metastasis. As autophagy is a double-edged sword in tumors, treatment of cancer via regulation of autophagy is extremely complicated. Therefore, understanding the relationship between tumor autophagy and the tumor microenvironment is extremely important. As the immune milieu plays an important role in tumor development, immunotherapy has become a promising form of cancer therapy. A multi-pronged treatment approach using immunotherapy and molecular targets may become the major direction for future cancer treatments. This article reviews existing knowledge regarding the immune factors in the tumor microenvironment and the status of tumor autophagy research. MDPI 2017-07-19 /pmc/articles/PMC5536054/ /pubmed/28753959 http://dx.doi.org/10.3390/ijms18071566 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Chia-Jung
Liao, Wan-Ting
Wu, Meng-Yu
Chu, Pei-Yi
New Insights into the Role of Autophagy in Tumor Immune Microenvironment
title New Insights into the Role of Autophagy in Tumor Immune Microenvironment
title_full New Insights into the Role of Autophagy in Tumor Immune Microenvironment
title_fullStr New Insights into the Role of Autophagy in Tumor Immune Microenvironment
title_full_unstemmed New Insights into the Role of Autophagy in Tumor Immune Microenvironment
title_short New Insights into the Role of Autophagy in Tumor Immune Microenvironment
title_sort new insights into the role of autophagy in tumor immune microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536054/
https://www.ncbi.nlm.nih.gov/pubmed/28753959
http://dx.doi.org/10.3390/ijms18071566
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