Cargando…
Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications
Several miRNAs are expressed in human gestational tissue, and some have been shown to be associated with placental dysfunction and complicated pregnancy outcomes. To investigate the roles of miR-346 and miR-582-3p in adverse obstetric events, we analyzed these 2 miRNAs in three samples (maternal blo...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536058/ https://www.ncbi.nlm.nih.gov/pubmed/28753968 http://dx.doi.org/10.3390/ijms18071570 |
_version_ | 1783253957446991872 |
---|---|
author | Tsai, Pei-Yin Li, Sheng-Hsiang Chen, Wan-Ni Tsai, Hui-Ling Su, Mei-Tsz |
author_facet | Tsai, Pei-Yin Li, Sheng-Hsiang Chen, Wan-Ni Tsai, Hui-Ling Su, Mei-Tsz |
author_sort | Tsai, Pei-Yin |
collection | PubMed |
description | Several miRNAs are expressed in human gestational tissue, and some have been shown to be associated with placental dysfunction and complicated pregnancy outcomes. To investigate the roles of miR-346 and miR-582-3p in adverse obstetric events, we analyzed these 2 miRNAs in three samples (maternal blood, umbilical cord blood and placenta) obtained from pregnant women in four groups, including healthy control (n = 60), preeclampsia (n = 31), preterm delivery (n = 29) and small for gestational age (n = 19) patients. The expression levels of miR-346 and miR-582-3p in all included adverse obstetric outcome groups were significantly higher in the maternal plasma samples but lower in the placenta samples (all p value < 0.05). In addition, the miR-346 expression levels in fetal cord blood were also significantly lower in all of the included adverse obstetric outcome groups (all p < 0.05). Multivariate analysis of the three specimens after adjusting for maternal age and gestational age at delivery gave the same results. In conclusion, aberrant miR-346 and miR-582-3p expression level in pregnancy was associated with multiple maternal and fetal complications. Their differential expression in maternal blood, umbilical cord blood and placenta could be potential biomarkers or therapeutic targets for adverse obstetric outcomes |
format | Online Article Text |
id | pubmed-5536058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55360582017-08-04 Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications Tsai, Pei-Yin Li, Sheng-Hsiang Chen, Wan-Ni Tsai, Hui-Ling Su, Mei-Tsz Int J Mol Sci Article Several miRNAs are expressed in human gestational tissue, and some have been shown to be associated with placental dysfunction and complicated pregnancy outcomes. To investigate the roles of miR-346 and miR-582-3p in adverse obstetric events, we analyzed these 2 miRNAs in three samples (maternal blood, umbilical cord blood and placenta) obtained from pregnant women in four groups, including healthy control (n = 60), preeclampsia (n = 31), preterm delivery (n = 29) and small for gestational age (n = 19) patients. The expression levels of miR-346 and miR-582-3p in all included adverse obstetric outcome groups were significantly higher in the maternal plasma samples but lower in the placenta samples (all p value < 0.05). In addition, the miR-346 expression levels in fetal cord blood were also significantly lower in all of the included adverse obstetric outcome groups (all p < 0.05). Multivariate analysis of the three specimens after adjusting for maternal age and gestational age at delivery gave the same results. In conclusion, aberrant miR-346 and miR-582-3p expression level in pregnancy was associated with multiple maternal and fetal complications. Their differential expression in maternal blood, umbilical cord blood and placenta could be potential biomarkers or therapeutic targets for adverse obstetric outcomes MDPI 2017-07-19 /pmc/articles/PMC5536058/ /pubmed/28753968 http://dx.doi.org/10.3390/ijms18071570 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tsai, Pei-Yin Li, Sheng-Hsiang Chen, Wan-Ni Tsai, Hui-Ling Su, Mei-Tsz Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications |
title | Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications |
title_full | Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications |
title_fullStr | Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications |
title_full_unstemmed | Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications |
title_short | Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications |
title_sort | differential mir-346 and mir-582-3p expression in association with selected maternal and fetal complications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536058/ https://www.ncbi.nlm.nih.gov/pubmed/28753968 http://dx.doi.org/10.3390/ijms18071570 |
work_keys_str_mv | AT tsaipeiyin differentialmir346andmir5823pexpressioninassociationwithselectedmaternalandfetalcomplications AT lishenghsiang differentialmir346andmir5823pexpressioninassociationwithselectedmaternalandfetalcomplications AT chenwanni differentialmir346andmir5823pexpressioninassociationwithselectedmaternalandfetalcomplications AT tsaihuiling differentialmir346andmir5823pexpressioninassociationwithselectedmaternalandfetalcomplications AT sumeitsz differentialmir346andmir5823pexpressioninassociationwithselectedmaternalandfetalcomplications |