DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol

PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance. In this review, we focus on recent advances in biochemical and crystallographic studies of P...

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Detalles Bibliográficos
Autores principales: Boldinova, Elizaveta O., Wanrooij, Paulina H., Shilkin, Evgeniy S., Wanrooij, Sjoerd, Makarova, Alena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536071/
https://www.ncbi.nlm.nih.gov/pubmed/28754021
http://dx.doi.org/10.3390/ijms18071584
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author Boldinova, Elizaveta O.
Wanrooij, Paulina H.
Shilkin, Evgeniy S.
Wanrooij, Sjoerd
Makarova, Alena V.
author_facet Boldinova, Elizaveta O.
Wanrooij, Paulina H.
Shilkin, Evgeniy S.
Wanrooij, Sjoerd
Makarova, Alena V.
author_sort Boldinova, Elizaveta O.
collection PubMed
description PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance. In this review, we focus on recent advances in biochemical and crystallographic studies of PrimPol, as well as in identification of new protein-protein interaction partners. Furthermore, we discuss the possible functions of PrimPol in both the nucleus and the mitochondria.
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spelling pubmed-55360712017-08-04 DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol Boldinova, Elizaveta O. Wanrooij, Paulina H. Shilkin, Evgeniy S. Wanrooij, Sjoerd Makarova, Alena V. Int J Mol Sci Review PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance. In this review, we focus on recent advances in biochemical and crystallographic studies of PrimPol, as well as in identification of new protein-protein interaction partners. Furthermore, we discuss the possible functions of PrimPol in both the nucleus and the mitochondria. MDPI 2017-07-21 /pmc/articles/PMC5536071/ /pubmed/28754021 http://dx.doi.org/10.3390/ijms18071584 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boldinova, Elizaveta O.
Wanrooij, Paulina H.
Shilkin, Evgeniy S.
Wanrooij, Sjoerd
Makarova, Alena V.
DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol
title DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol
title_full DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol
title_fullStr DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol
title_full_unstemmed DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol
title_short DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol
title_sort dna damage tolerance by eukaryotic dna polymerase and primase primpol
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536071/
https://www.ncbi.nlm.nih.gov/pubmed/28754021
http://dx.doi.org/10.3390/ijms18071584
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