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An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity

The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived individuals, in spite of optimally maintaining most...

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Autores principales: Martínez de Toda, Irene, Vida, Carmen, De la Fuente, Mónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536085/
https://www.ncbi.nlm.nih.gov/pubmed/28737707
http://dx.doi.org/10.3390/ijms18071598
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author Martínez de Toda, Irene
Vida, Carmen
De la Fuente, Mónica
author_facet Martínez de Toda, Irene
Vida, Carmen
De la Fuente, Mónica
author_sort Martínez de Toda, Irene
collection PubMed
description The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived individuals, in spite of optimally maintaining most of the functions of the immune system, also seem to show an impaired proliferative response. Thus, it was hypothesized that these individuals may have distinct evolution times in this proliferation and a different modulatory capacity through their cytokine release profiles. An individualized longitudinal study was performed on female ICR-CD1 mice, starting at the adult age (40 weeks old), analyzing the proliferation of peritoneal leukocytes at different ages in both basal conditions and in the presence of the mitogen Concanavalin A, for 4, 24 and 48 h of culture. The cytokine secretions (IL-2, IL-17, IL-1β, IL-6, TNF-α and IL-10) in the same cultures were also studied. Long-lived mice show a high proliferative capacity after short incubation times and, despite experiencing a functional decline when they are old, are able to compensate this decrease with an appropriate modulation of the lymphoproliferative response and cytokine release. This could explain their elevated resistance to infections and high longevity.
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spelling pubmed-55360852017-08-04 An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity Martínez de Toda, Irene Vida, Carmen De la Fuente, Mónica Int J Mol Sci Article The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived individuals, in spite of optimally maintaining most of the functions of the immune system, also seem to show an impaired proliferative response. Thus, it was hypothesized that these individuals may have distinct evolution times in this proliferation and a different modulatory capacity through their cytokine release profiles. An individualized longitudinal study was performed on female ICR-CD1 mice, starting at the adult age (40 weeks old), analyzing the proliferation of peritoneal leukocytes at different ages in both basal conditions and in the presence of the mitogen Concanavalin A, for 4, 24 and 48 h of culture. The cytokine secretions (IL-2, IL-17, IL-1β, IL-6, TNF-α and IL-10) in the same cultures were also studied. Long-lived mice show a high proliferative capacity after short incubation times and, despite experiencing a functional decline when they are old, are able to compensate this decrease with an appropriate modulation of the lymphoproliferative response and cytokine release. This could explain their elevated resistance to infections and high longevity. MDPI 2017-07-24 /pmc/articles/PMC5536085/ /pubmed/28737707 http://dx.doi.org/10.3390/ijms18071598 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martínez de Toda, Irene
Vida, Carmen
De la Fuente, Mónica
An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity
title An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity
title_full An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity
title_fullStr An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity
title_full_unstemmed An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity
title_short An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity
title_sort appropriate modulation of lymphoproliferative response and cytokine release as possible contributors to longevity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536085/
https://www.ncbi.nlm.nih.gov/pubmed/28737707
http://dx.doi.org/10.3390/ijms18071598
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