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An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity
The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived individuals, in spite of optimally maintaining most...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536085/ https://www.ncbi.nlm.nih.gov/pubmed/28737707 http://dx.doi.org/10.3390/ijms18071598 |
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author | Martínez de Toda, Irene Vida, Carmen De la Fuente, Mónica |
author_facet | Martínez de Toda, Irene Vida, Carmen De la Fuente, Mónica |
author_sort | Martínez de Toda, Irene |
collection | PubMed |
description | The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived individuals, in spite of optimally maintaining most of the functions of the immune system, also seem to show an impaired proliferative response. Thus, it was hypothesized that these individuals may have distinct evolution times in this proliferation and a different modulatory capacity through their cytokine release profiles. An individualized longitudinal study was performed on female ICR-CD1 mice, starting at the adult age (40 weeks old), analyzing the proliferation of peritoneal leukocytes at different ages in both basal conditions and in the presence of the mitogen Concanavalin A, for 4, 24 and 48 h of culture. The cytokine secretions (IL-2, IL-17, IL-1β, IL-6, TNF-α and IL-10) in the same cultures were also studied. Long-lived mice show a high proliferative capacity after short incubation times and, despite experiencing a functional decline when they are old, are able to compensate this decrease with an appropriate modulation of the lymphoproliferative response and cytokine release. This could explain their elevated resistance to infections and high longevity. |
format | Online Article Text |
id | pubmed-5536085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55360852017-08-04 An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity Martínez de Toda, Irene Vida, Carmen De la Fuente, Mónica Int J Mol Sci Article The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-lived individuals, in spite of optimally maintaining most of the functions of the immune system, also seem to show an impaired proliferative response. Thus, it was hypothesized that these individuals may have distinct evolution times in this proliferation and a different modulatory capacity through their cytokine release profiles. An individualized longitudinal study was performed on female ICR-CD1 mice, starting at the adult age (40 weeks old), analyzing the proliferation of peritoneal leukocytes at different ages in both basal conditions and in the presence of the mitogen Concanavalin A, for 4, 24 and 48 h of culture. The cytokine secretions (IL-2, IL-17, IL-1β, IL-6, TNF-α and IL-10) in the same cultures were also studied. Long-lived mice show a high proliferative capacity after short incubation times and, despite experiencing a functional decline when they are old, are able to compensate this decrease with an appropriate modulation of the lymphoproliferative response and cytokine release. This could explain their elevated resistance to infections and high longevity. MDPI 2017-07-24 /pmc/articles/PMC5536085/ /pubmed/28737707 http://dx.doi.org/10.3390/ijms18071598 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martínez de Toda, Irene Vida, Carmen De la Fuente, Mónica An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity |
title | An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity |
title_full | An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity |
title_fullStr | An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity |
title_full_unstemmed | An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity |
title_short | An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity |
title_sort | appropriate modulation of lymphoproliferative response and cytokine release as possible contributors to longevity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536085/ https://www.ncbi.nlm.nih.gov/pubmed/28737707 http://dx.doi.org/10.3390/ijms18071598 |
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