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Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion
Immature or semi-mature dendritic cells (DCs) represent tolerogenic maturation stages that can convert naive T cells into Foxp3(+) induced regulatory T cells (iTreg). Here we found that murine bone marrow-derived DCs (BM-DCs) treated with cholera toxin (CT) matured by up-regulating MHC-II and costim...
Autores principales: | Silva-Vilches, Cinthia, Pletinckx, Katrien, Lohnert, Miriam, Pavlovic, Vladimir, Ashour, Diyaaeldin, John, Vini, Vendelova, Emilia, Kneitz, Susanne, Zhou, Jie, Chen, Rena, Reinheckel, Thomas, Mueller, Thomas D., Bodem, Jochen, Lutz, Manfred B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536293/ https://www.ncbi.nlm.nih.gov/pubmed/28759565 http://dx.doi.org/10.1371/journal.pone.0178114 |
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