Cargando…
The effect of disease and respiration on airway shape in patients with moderate persistent asthma
Computational models of gas transport and aerosol deposition frequently utilize idealized models of bronchial tree structure, where airways are considered a network of bifurcating cylinders. However, changes in the shape of the lung during respiration affect the geometry of the airways, especially i...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536319/ https://www.ncbi.nlm.nih.gov/pubmed/28759656 http://dx.doi.org/10.1371/journal.pone.0182052 |
_version_ | 1783253999263154176 |
---|---|
author | Montesantos, Spyridon Katz, Ira Venegas, Jose Pichelin, Marine Caillibotte, Georges |
author_facet | Montesantos, Spyridon Katz, Ira Venegas, Jose Pichelin, Marine Caillibotte, Georges |
author_sort | Montesantos, Spyridon |
collection | PubMed |
description | Computational models of gas transport and aerosol deposition frequently utilize idealized models of bronchial tree structure, where airways are considered a network of bifurcating cylinders. However, changes in the shape of the lung during respiration affect the geometry of the airways, especially in disease conditions. In this study, the internal airway geometry was examined, concentrating on comparisons between mean lung volume (MLV) and total lung capacity (TLC). A set of High Resolution CT images were acquired during breath hold on a group of moderate persistent asthmatics at MLV and TLC after challenge with a broncho-constrictor (methacholine) and the airway trees were segmented and measured. The airway hydraulic diameter (Dh) was calculated through the use of average lumen area (Ai) and average internal perimeter (Pi) at both lung volumes and was found to be systematically higher at TLC by 13.5±9% on average, with the lower lobes displaying higher percent change in comparison to the lower lobes. The average internal diameter (Din) was evaluated to be 12.4±6.8% (MLV) and 10.8±6.3% (TLC) lower than the Dh, for all the examined bronchi, a result displaying statistical significance. Finally, the airway distensibility per bronchial segment and per generation was calculated to have an average value of 0.45±0.28, exhibiting high variability both between and within lung regions and generations. Mixed constriction/dilation patterns were recorded between the lung volumes, where a number of airways either failed to dilate or even constricted when observed at TLC. We conclude that the Dh is higher than Din, a fact that may have considerable effects on bronchial resistance or airway loss at proximal regions. Differences in caliber changes between lung regions are indicative of asthma-expression variability in the lung. However, airway distensibility at generation 3 seems to predict distensibility more distally. |
format | Online Article Text |
id | pubmed-5536319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55363192017-08-07 The effect of disease and respiration on airway shape in patients with moderate persistent asthma Montesantos, Spyridon Katz, Ira Venegas, Jose Pichelin, Marine Caillibotte, Georges PLoS One Research Article Computational models of gas transport and aerosol deposition frequently utilize idealized models of bronchial tree structure, where airways are considered a network of bifurcating cylinders. However, changes in the shape of the lung during respiration affect the geometry of the airways, especially in disease conditions. In this study, the internal airway geometry was examined, concentrating on comparisons between mean lung volume (MLV) and total lung capacity (TLC). A set of High Resolution CT images were acquired during breath hold on a group of moderate persistent asthmatics at MLV and TLC after challenge with a broncho-constrictor (methacholine) and the airway trees were segmented and measured. The airway hydraulic diameter (Dh) was calculated through the use of average lumen area (Ai) and average internal perimeter (Pi) at both lung volumes and was found to be systematically higher at TLC by 13.5±9% on average, with the lower lobes displaying higher percent change in comparison to the lower lobes. The average internal diameter (Din) was evaluated to be 12.4±6.8% (MLV) and 10.8±6.3% (TLC) lower than the Dh, for all the examined bronchi, a result displaying statistical significance. Finally, the airway distensibility per bronchial segment and per generation was calculated to have an average value of 0.45±0.28, exhibiting high variability both between and within lung regions and generations. Mixed constriction/dilation patterns were recorded between the lung volumes, where a number of airways either failed to dilate or even constricted when observed at TLC. We conclude that the Dh is higher than Din, a fact that may have considerable effects on bronchial resistance or airway loss at proximal regions. Differences in caliber changes between lung regions are indicative of asthma-expression variability in the lung. However, airway distensibility at generation 3 seems to predict distensibility more distally. Public Library of Science 2017-07-31 /pmc/articles/PMC5536319/ /pubmed/28759656 http://dx.doi.org/10.1371/journal.pone.0182052 Text en © 2017 Montesantos et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Montesantos, Spyridon Katz, Ira Venegas, Jose Pichelin, Marine Caillibotte, Georges The effect of disease and respiration on airway shape in patients with moderate persistent asthma |
title | The effect of disease and respiration on airway shape in patients with moderate persistent asthma |
title_full | The effect of disease and respiration on airway shape in patients with moderate persistent asthma |
title_fullStr | The effect of disease and respiration on airway shape in patients with moderate persistent asthma |
title_full_unstemmed | The effect of disease and respiration on airway shape in patients with moderate persistent asthma |
title_short | The effect of disease and respiration on airway shape in patients with moderate persistent asthma |
title_sort | effect of disease and respiration on airway shape in patients with moderate persistent asthma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536319/ https://www.ncbi.nlm.nih.gov/pubmed/28759656 http://dx.doi.org/10.1371/journal.pone.0182052 |
work_keys_str_mv | AT montesantosspyridon theeffectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma AT katzira theeffectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma AT venegasjose theeffectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma AT pichelinmarine theeffectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma AT caillibottegeorges theeffectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma AT montesantosspyridon effectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma AT katzira effectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma AT venegasjose effectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma AT pichelinmarine effectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma AT caillibottegeorges effectofdiseaseandrespirationonairwayshapeinpatientswithmoderatepersistentasthma |