The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast

Mutations in the ribosomal protein Rpl10 (uL16) can be drivers of T-cell acute lymphoblastic leukemia (T-ALL). We previously showed that these T-ALL mutations disrupt late cytoplasmic maturation of the 60S ribosomal subunit, blocking the release of the trans-acting factors Nmd3 and Tif6 in S. cerevi...

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Detalles Bibliográficos
Autores principales: Patchett, Stephanie, Musalgaonkar, Sharmishtha, Malyutin, Andrey G., Johnson, Arlen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536393/
https://www.ncbi.nlm.nih.gov/pubmed/28715419
http://dx.doi.org/10.1371/journal.pgen.1006894

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