Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis

Huntington’s Disease (HD) is an autosomal dominant progressive neurodegenerative disorder characterized by cognitive, behavioral and motor dysfunctions. HD is caused by a CAG repeat expansion in exon 1 of the HD gene that is translated into an expanded polyglutamine tract in the encoded protein, hun...

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Detalles Bibliográficos
Autores principales: Dietrich, Paula, Johnson, Irudayam Maria, Alli, Shanta, Dragatsis, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536499/
https://www.ncbi.nlm.nih.gov/pubmed/28715425
http://dx.doi.org/10.1371/journal.pgen.1006846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536499/
https://www.ncbi.nlm.nih.gov/pubmed/28715425
http://dx.doi.org/10.1371/journal.pgen.1006846

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