S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis

OBJECTIVE: To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis. METHODS: Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and...

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Autores principales: Chimenti, Maria Sole, Triggianese, Paola, Botti, Elisabetta, Narcisi, Alessandra, Conigliaro, Paola, Giunta, Alessandro, Teoli, Miriam, Perricone, Roberto, Costanzo, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Gene/Molecular Research on Immune-Mediated Diseases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536520/
https://www.ncbi.nlm.nih.gov/pubmed/27683136
http://dx.doi.org/10.1177/0300060515598900
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author Chimenti, Maria Sole
Triggianese, Paola
Botti, Elisabetta
Narcisi, Alessandra
Conigliaro, Paola
Giunta, Alessandro
Teoli, Miriam
Perricone, Roberto
Costanzo, Antonio
author_facet Chimenti, Maria Sole
Triggianese, Paola
Botti, Elisabetta
Narcisi, Alessandra
Conigliaro, Paola
Giunta, Alessandro
Teoli, Miriam
Perricone, Roberto
Costanzo, Antonio
author_sort Chimenti, Maria Sole
collection PubMed
description OBJECTIVE: To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis. METHODS: Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and semiquantitative polymerase chain reaction. RESULTS: The study included biopsies from nine patients with psoriatic arthritis and nine control subjects. S100A8 and S100A9 were present at visibly higher levels in psoriatic plaques compared with normal skin samples. S100A8 and S100A9 RNA levels were significantly higher in the peripheral region of plaques compared with the central region. CONCLUSION: Both S100A8 and S100A9 may represent good therapeutic targets in psoriasis and psoriatic arthritis.
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spelling pubmed-55365202017-10-03 S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis Chimenti, Maria Sole Triggianese, Paola Botti, Elisabetta Narcisi, Alessandra Conigliaro, Paola Giunta, Alessandro Teoli, Miriam Perricone, Roberto Costanzo, Antonio J Int Med Res Gene/Molecular Research on Immune-Mediated Diseases OBJECTIVE: To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis. METHODS: Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and semiquantitative polymerase chain reaction. RESULTS: The study included biopsies from nine patients with psoriatic arthritis and nine control subjects. S100A8 and S100A9 were present at visibly higher levels in psoriatic plaques compared with normal skin samples. S100A8 and S100A9 RNA levels were significantly higher in the peripheral region of plaques compared with the central region. CONCLUSION: Both S100A8 and S100A9 may represent good therapeutic targets in psoriasis and psoriatic arthritis. SAGE Publications 2016-09-28 2016-09 /pmc/articles/PMC5536520/ /pubmed/27683136 http://dx.doi.org/10.1177/0300060515598900 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Gene/Molecular Research on Immune-Mediated Diseases
Chimenti, Maria Sole
Triggianese, Paola
Botti, Elisabetta
Narcisi, Alessandra
Conigliaro, Paola
Giunta, Alessandro
Teoli, Miriam
Perricone, Roberto
Costanzo, Antonio
S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
title S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
title_full S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
title_fullStr S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
title_full_unstemmed S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
title_short S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
title_sort s100a8/a9 in psoriatic plaques from patients with psoriatic arthritis
topic Gene/Molecular Research on Immune-Mediated Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536520/
https://www.ncbi.nlm.nih.gov/pubmed/27683136
http://dx.doi.org/10.1177/0300060515598900
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