Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study

AIM: To investigate the role of body mass index (BMI) and weight in the long-term efficacy of etanercept in patients with psoriasis. METHODS: Medical records were retrospectively analysed. Extracted data included weight, BMI, comorbidities and psoriasis area severity index (PASI). Patients were stra...

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Autores principales: Giunta, Alessandro, Babino, Graziella, Ruzzetti, Manuela, Manetta, Sara, Chimenti, Sergio, Esposito, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Immuno-Mediated Diseases and Obesity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536536/
https://www.ncbi.nlm.nih.gov/pubmed/27683144
http://dx.doi.org/10.1177/0300060515593254
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author Giunta, Alessandro
Babino, Graziella
Ruzzetti, Manuela
Manetta, Sara
Chimenti, Sergio
Esposito, Maria
author_facet Giunta, Alessandro
Babino, Graziella
Ruzzetti, Manuela
Manetta, Sara
Chimenti, Sergio
Esposito, Maria
author_sort Giunta, Alessandro
collection PubMed
description AIM: To investigate the role of body mass index (BMI) and weight in the long-term efficacy of etanercept in patients with psoriasis. METHODS: Medical records were retrospectively analysed. Extracted data included weight, BMI, comorbidities and psoriasis area severity index (PASI). Patients were stratified by weight (<80 kg or ≥80 kg) and BMI (healthy, BMI 22 – 24.99 kg/m(2); overweight, BMI 25 – 29.99 kg/m(2); obese, BMI ≥30 kg/m(2)). RESULTS: The study included 66 patients. Body weight had no effect on etanercept efficacy. There was a significant reduction in etanercept efficacy in obese patients (n = 12) compared with healthy weight (n = 33) or overweight (n = 21) patients. CONCLUSION: Obesity has a negative effect on the efficacy of etanercept in psoriasis.
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spelling pubmed-55365362017-10-03 Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study Giunta, Alessandro Babino, Graziella Ruzzetti, Manuela Manetta, Sara Chimenti, Sergio Esposito, Maria J Int Med Res Immuno-Mediated Diseases and Obesity AIM: To investigate the role of body mass index (BMI) and weight in the long-term efficacy of etanercept in patients with psoriasis. METHODS: Medical records were retrospectively analysed. Extracted data included weight, BMI, comorbidities and psoriasis area severity index (PASI). Patients were stratified by weight (<80 kg or ≥80 kg) and BMI (healthy, BMI 22 – 24.99 kg/m(2); overweight, BMI 25 – 29.99 kg/m(2); obese, BMI ≥30 kg/m(2)). RESULTS: The study included 66 patients. Body weight had no effect on etanercept efficacy. There was a significant reduction in etanercept efficacy in obese patients (n = 12) compared with healthy weight (n = 33) or overweight (n = 21) patients. CONCLUSION: Obesity has a negative effect on the efficacy of etanercept in psoriasis. SAGE Publications 2016-09-28 2016-09 /pmc/articles/PMC5536536/ /pubmed/27683144 http://dx.doi.org/10.1177/0300060515593254 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Immuno-Mediated Diseases and Obesity
Giunta, Alessandro
Babino, Graziella
Ruzzetti, Manuela
Manetta, Sara
Chimenti, Sergio
Esposito, Maria
Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study
title Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study
title_full Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study
title_fullStr Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study
title_full_unstemmed Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study
title_short Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study
title_sort influence of body mass index and weight on etanercept efficacy in patients with psoriasis: a retrospective study
topic Immuno-Mediated Diseases and Obesity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536536/
https://www.ncbi.nlm.nih.gov/pubmed/27683144
http://dx.doi.org/10.1177/0300060515593254
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