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Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt

OBJECTIVE: To describe the characteristics of hepatitis E virus (HEV) infection in a cohort of children from Upper Egypt using data from a large multicentre prospective study of acute viral hepatitis (AVH). METHODS: Data from subjects aged 2–18 years with AVH or close contacts of those with AVH foun...

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Autores principales: Hasan, Gamal, Assiri, Asaad, Marzuuk, Naglaa, Daef, Enas, Abdelwahab, Sayed, Ahmed, Ahmed, Mohamad, Ismail, Al-Eyadhy, Ayman, Alhaboob, Ali, Temsah, Mohamad-Hani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536550/
https://www.ncbi.nlm.nih.gov/pubmed/27688687
http://dx.doi.org/10.1177/0300060516659575
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author Hasan, Gamal
Assiri, Asaad
Marzuuk, Naglaa
Daef, Enas
Abdelwahab, Sayed
Ahmed, Ahmed
Mohamad, Ismail
Al-Eyadhy, Ayman
Alhaboob, Ali
Temsah, Mohamad-Hani
author_facet Hasan, Gamal
Assiri, Asaad
Marzuuk, Naglaa
Daef, Enas
Abdelwahab, Sayed
Ahmed, Ahmed
Mohamad, Ismail
Al-Eyadhy, Ayman
Alhaboob, Ali
Temsah, Mohamad-Hani
author_sort Hasan, Gamal
collection PubMed
description OBJECTIVE: To describe the characteristics of hepatitis E virus (HEV) infection in a cohort of children from Upper Egypt using data from a large multicentre prospective study of acute viral hepatitis (AVH). METHODS: Data from subjects aged 2–18 years with AVH or close contacts of those with AVH found to have asymptomatic AVH were included in the analysis. Information concerning medical history, clinical examination, liver function tests and screening for hepatotropic viruses was recorded and analysed. RESULTS: A total of 123 patients (73 boys, 50 girls) were included in the analysis. Of these, 33 (26.8%) had HEV infection, 17 (13.8%) had hepatitis A virus infection, 10 (8.1%) had hepatitis B virus infection, 14 (11.4%) had cytomegalovirus hepatitis, five (4.1%) had autoimmune hepatitis, 11 (8.9%) had hepatitis due to mixed viral infections and 33 (26.8%) had non A–E hepatitis. Overall, 38 (30.9%) had infection with HEV. HEV infection was significantly higher among those using underground wells as a water source compared with tap water. Liver enzymes were significantly raised in patients with non-HEV infection compared with those with HEV infection. CONCLUSIONS: HEV is a significant cause of AVH among children in Upper Egypt. Contamination of drinking water appears to be a major source of infection. Screening for HEV should be considered in all Egyptian children with AVH.
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spelling pubmed-55365502017-10-03 Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt Hasan, Gamal Assiri, Asaad Marzuuk, Naglaa Daef, Enas Abdelwahab, Sayed Ahmed, Ahmed Mohamad, Ismail Al-Eyadhy, Ayman Alhaboob, Ali Temsah, Mohamad-Hani J Int Med Res Clinical Reports OBJECTIVE: To describe the characteristics of hepatitis E virus (HEV) infection in a cohort of children from Upper Egypt using data from a large multicentre prospective study of acute viral hepatitis (AVH). METHODS: Data from subjects aged 2–18 years with AVH or close contacts of those with AVH found to have asymptomatic AVH were included in the analysis. Information concerning medical history, clinical examination, liver function tests and screening for hepatotropic viruses was recorded and analysed. RESULTS: A total of 123 patients (73 boys, 50 girls) were included in the analysis. Of these, 33 (26.8%) had HEV infection, 17 (13.8%) had hepatitis A virus infection, 10 (8.1%) had hepatitis B virus infection, 14 (11.4%) had cytomegalovirus hepatitis, five (4.1%) had autoimmune hepatitis, 11 (8.9%) had hepatitis due to mixed viral infections and 33 (26.8%) had non A–E hepatitis. Overall, 38 (30.9%) had infection with HEV. HEV infection was significantly higher among those using underground wells as a water source compared with tap water. Liver enzymes were significantly raised in patients with non-HEV infection compared with those with HEV infection. CONCLUSIONS: HEV is a significant cause of AVH among children in Upper Egypt. Contamination of drinking water appears to be a major source of infection. Screening for HEV should be considered in all Egyptian children with AVH. SAGE Publications 2016-09-29 2016-10 /pmc/articles/PMC5536550/ /pubmed/27688687 http://dx.doi.org/10.1177/0300060516659575 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Reports
Hasan, Gamal
Assiri, Asaad
Marzuuk, Naglaa
Daef, Enas
Abdelwahab, Sayed
Ahmed, Ahmed
Mohamad, Ismail
Al-Eyadhy, Ayman
Alhaboob, Ali
Temsah, Mohamad-Hani
Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt
title Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt
title_full Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt
title_fullStr Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt
title_full_unstemmed Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt
title_short Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt
title_sort incidence and characteristics of hepatitis e virus infection in children in assiut, upper egypt
topic Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536550/
https://www.ncbi.nlm.nih.gov/pubmed/27688687
http://dx.doi.org/10.1177/0300060516659575
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