Genetic polymorphisms associated with heart failure: A literature review

OBJECTIVE: To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure. METHODS: Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and Februar...

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Detalles Bibliográficos
Autores principales: Guo, Mengqi, Guo, Guanlun, Ji, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536573/
https://www.ncbi.nlm.nih.gov/pubmed/26769713
http://dx.doi.org/10.1177/0300060515604755
Descripción
Sumario:OBJECTIVE: To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure. METHODS: Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015. RESULTS: Eighty-two articles covering 29 genes and 39 polymorphisms were identified. CONCLUSION: Genetic association studies of heart failure have been highly controversial. There may be interaction or synergism of several genetic variants that together result in the ultimate pathological phenotype for heart failure.

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