Genetic polymorphisms associated with heart failure: A literature review

OBJECTIVE: To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure. METHODS: Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and Februar...

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Detalles Bibliográficos
Autores principales: Guo, Mengqi, Guo, Guanlun, Ji, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536573/
https://www.ncbi.nlm.nih.gov/pubmed/26769713
http://dx.doi.org/10.1177/0300060515604755
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author Guo, Mengqi
Guo, Guanlun
Ji, Xiaoping
author_facet Guo, Mengqi
Guo, Guanlun
Ji, Xiaoping
author_sort Guo, Mengqi
collection PubMed
description OBJECTIVE: To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure. METHODS: Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015. RESULTS: Eighty-two articles covering 29 genes and 39 polymorphisms were identified. CONCLUSION: Genetic association studies of heart failure have been highly controversial. There may be interaction or synergism of several genetic variants that together result in the ultimate pathological phenotype for heart failure.
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spelling pubmed-55365732017-10-03 Genetic polymorphisms associated with heart failure: A literature review Guo, Mengqi Guo, Guanlun Ji, Xiaoping J Int Med Res Review OBJECTIVE: To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure. METHODS: Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015. RESULTS: Eighty-two articles covering 29 genes and 39 polymorphisms were identified. CONCLUSION: Genetic association studies of heart failure have been highly controversial. There may be interaction or synergism of several genetic variants that together result in the ultimate pathological phenotype for heart failure. SAGE Publications 2016-01-14 2016-02 /pmc/articles/PMC5536573/ /pubmed/26769713 http://dx.doi.org/10.1177/0300060515604755 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Guo, Mengqi
Guo, Guanlun
Ji, Xiaoping
Genetic polymorphisms associated with heart failure: A literature review
title Genetic polymorphisms associated with heart failure: A literature review
title_full Genetic polymorphisms associated with heart failure: A literature review
title_fullStr Genetic polymorphisms associated with heart failure: A literature review
title_full_unstemmed Genetic polymorphisms associated with heart failure: A literature review
title_short Genetic polymorphisms associated with heart failure: A literature review
title_sort genetic polymorphisms associated with heart failure: a literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536573/
https://www.ncbi.nlm.nih.gov/pubmed/26769713
http://dx.doi.org/10.1177/0300060515604755
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