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Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population
OBJECTIVE: To investigate the relationship between hyperuricemia and coronary heart disease (CHD) risk based on the Framingham risk score (FRS) in a middle-aged and elderly Chinese population. METHODS: This cross-sectional study enrolled patients undergoing routine check-ups at Xiangya Hospital betw...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536609/ https://www.ncbi.nlm.nih.gov/pubmed/28222629 http://dx.doi.org/10.1177/0300060516673923 |
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author | Yang, Ye Tian, Jian Zeng, Chao Wei, Jie Li, Liang-Jun Xie, Xi Yang, Tuo Li, Hui Lei, Guang-Hua |
author_facet | Yang, Ye Tian, Jian Zeng, Chao Wei, Jie Li, Liang-Jun Xie, Xi Yang, Tuo Li, Hui Lei, Guang-Hua |
author_sort | Yang, Ye |
collection | PubMed |
description | OBJECTIVE: To investigate the relationship between hyperuricemia and coronary heart disease (CHD) risk based on the Framingham risk score (FRS) in a middle-aged and elderly Chinese population. METHODS: This cross-sectional study enrolled patients undergoing routine check-ups at Xiangya Hospital between October 2013 and November 2014. Hyperuricemia was defined as uric acid ≥416 mmol/l for males and ≥360 mmol/l for females. A 10-year CHD risk was calculated from FRS. A multivariable logistic analysis model was used to evaluate associations. RESULTS: Of the 6347 patients, 3415 (53.8%) were male, 1543 (24.3%) had a CHD risk ≥10% (i.e. intermediate and high risk) and the prevalence of hyperuricemia was 18.1% (n = 1148). After adjusting for potential confounding factors, the 10-year CHD risk was increased in patients with hyperuricemia compared with those without hyperuricemia by 0.28 times in the total population (odds ratio [OR] 1.28; 95% confidence interval [CI] 1.09, 1.48), by 0.25 times in the male population (OR 1.25; 95% CI 1.06, 1.47) and by 2.76 times in the female population (OR 3.76; 95% CI 2.08, 6.79). CONCLUSION: Hyperuricemia was positively associated with a 10-year risk of CHD suggesting that it might be an independent CHD risk factor in middle-aged and elderly individuals. |
format | Online Article Text |
id | pubmed-5536609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-55366092017-10-03 Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population Yang, Ye Tian, Jian Zeng, Chao Wei, Jie Li, Liang-Jun Xie, Xi Yang, Tuo Li, Hui Lei, Guang-Hua J Int Med Res Clinical Reports OBJECTIVE: To investigate the relationship between hyperuricemia and coronary heart disease (CHD) risk based on the Framingham risk score (FRS) in a middle-aged and elderly Chinese population. METHODS: This cross-sectional study enrolled patients undergoing routine check-ups at Xiangya Hospital between October 2013 and November 2014. Hyperuricemia was defined as uric acid ≥416 mmol/l for males and ≥360 mmol/l for females. A 10-year CHD risk was calculated from FRS. A multivariable logistic analysis model was used to evaluate associations. RESULTS: Of the 6347 patients, 3415 (53.8%) were male, 1543 (24.3%) had a CHD risk ≥10% (i.e. intermediate and high risk) and the prevalence of hyperuricemia was 18.1% (n = 1148). After adjusting for potential confounding factors, the 10-year CHD risk was increased in patients with hyperuricemia compared with those without hyperuricemia by 0.28 times in the total population (odds ratio [OR] 1.28; 95% confidence interval [CI] 1.09, 1.48), by 0.25 times in the male population (OR 1.25; 95% CI 1.06, 1.47) and by 2.76 times in the female population (OR 3.76; 95% CI 2.08, 6.79). CONCLUSION: Hyperuricemia was positively associated with a 10-year risk of CHD suggesting that it might be an independent CHD risk factor in middle-aged and elderly individuals. SAGE Publications 2017-01-12 2017-02 /pmc/articles/PMC5536609/ /pubmed/28222629 http://dx.doi.org/10.1177/0300060516673923 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Clinical Reports Yang, Ye Tian, Jian Zeng, Chao Wei, Jie Li, Liang-Jun Xie, Xi Yang, Tuo Li, Hui Lei, Guang-Hua Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population |
title | Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population |
title_full | Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population |
title_fullStr | Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population |
title_full_unstemmed | Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population |
title_short | Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population |
title_sort | relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly chinese population |
topic | Clinical Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536609/ https://www.ncbi.nlm.nih.gov/pubmed/28222629 http://dx.doi.org/10.1177/0300060516673923 |
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