Cargando…
Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case–control study
OBJECTIVE: To analyse the role of serum cartilage oligomeric matrix protein (COMP) levels in the differential diagnosis of rheumatoid arthritis (RA). METHODS: This case–control study analysed the clinical and laboratory characteristics of patients with RA and healthy control subjects. The diagnostic...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536618/ https://www.ncbi.nlm.nih.gov/pubmed/27217240 http://dx.doi.org/10.1177/0300060516639504 |
_version_ | 1783254046889476096 |
---|---|
author | Liu, Fengxia Wang, Xijuan Zhang, Xude Ren, Cuiai Xin, Jie |
author_facet | Liu, Fengxia Wang, Xijuan Zhang, Xude Ren, Cuiai Xin, Jie |
author_sort | Liu, Fengxia |
collection | PubMed |
description | OBJECTIVE: To analyse the role of serum cartilage oligomeric matrix protein (COMP) levels in the differential diagnosis of rheumatoid arthritis (RA). METHODS: This case–control study analysed the clinical and laboratory characteristics of patients with RA and healthy control subjects. The diagnostic ability of COMP for RA was evaluated by comparing it with anti-cyclic citrullinated peptide antibody levels. The sensitivity, specificity, positive and negative predictive values were calculated. RESULTS: The study enrolled 82 patients with RA and 34 healthy control subjects. The serum COMP level was significantly higher in patients with RA compared with control subjects (mean ± SD 29.51 ± 9.21 ng/ml versus 17.85 ± 5.55 ng/ml, respectively). The serum COMP level was significantly higher in patients with active RA compared with patients with RA in remission (mean ± SD 33.08 ± 8.80 ng/ml versus 24.94 ± 7.65 ng/ml, respectively). The cut-off value for COMP to discriminate patients with RA from healthy individuals was 21.51 ng/ml (sensitivity 0.817, specificity 0.882, positive predictive value 0.944, negative predictive value 0.667, and accuracy 0.836). CONCLUSION: The serum COMP level has the potential to be used as a biological marker for differentiating between patients with RA and healthy individuals. |
format | Online Article Text |
id | pubmed-5536618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-55366182017-10-03 Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case–control study Liu, Fengxia Wang, Xijuan Zhang, Xude Ren, Cuiai Xin, Jie J Int Med Res Clinical Reports OBJECTIVE: To analyse the role of serum cartilage oligomeric matrix protein (COMP) levels in the differential diagnosis of rheumatoid arthritis (RA). METHODS: This case–control study analysed the clinical and laboratory characteristics of patients with RA and healthy control subjects. The diagnostic ability of COMP for RA was evaluated by comparing it with anti-cyclic citrullinated peptide antibody levels. The sensitivity, specificity, positive and negative predictive values were calculated. RESULTS: The study enrolled 82 patients with RA and 34 healthy control subjects. The serum COMP level was significantly higher in patients with RA compared with control subjects (mean ± SD 29.51 ± 9.21 ng/ml versus 17.85 ± 5.55 ng/ml, respectively). The serum COMP level was significantly higher in patients with active RA compared with patients with RA in remission (mean ± SD 33.08 ± 8.80 ng/ml versus 24.94 ± 7.65 ng/ml, respectively). The cut-off value for COMP to discriminate patients with RA from healthy individuals was 21.51 ng/ml (sensitivity 0.817, specificity 0.882, positive predictive value 0.944, negative predictive value 0.667, and accuracy 0.836). CONCLUSION: The serum COMP level has the potential to be used as a biological marker for differentiating between patients with RA and healthy individuals. SAGE Publications 2016-05-23 2016-08 /pmc/articles/PMC5536618/ /pubmed/27217240 http://dx.doi.org/10.1177/0300060516639504 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Clinical Reports Liu, Fengxia Wang, Xijuan Zhang, Xude Ren, Cuiai Xin, Jie Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case–control study |
title | Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case–control study |
title_full | Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case–control study |
title_fullStr | Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case–control study |
title_full_unstemmed | Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case–control study |
title_short | Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case–control study |
title_sort | role of serum cartilage oligomeric matrix protein (comp) in the diagnosis of rheumatoid arthritis (ra): a case–control study |
topic | Clinical Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536618/ https://www.ncbi.nlm.nih.gov/pubmed/27217240 http://dx.doi.org/10.1177/0300060516639504 |
work_keys_str_mv | AT liufengxia roleofserumcartilageoligomericmatrixproteincompinthediagnosisofrheumatoidarthritisraacasecontrolstudy AT wangxijuan roleofserumcartilageoligomericmatrixproteincompinthediagnosisofrheumatoidarthritisraacasecontrolstudy AT zhangxude roleofserumcartilageoligomericmatrixproteincompinthediagnosisofrheumatoidarthritisraacasecontrolstudy AT rencuiai roleofserumcartilageoligomericmatrixproteincompinthediagnosisofrheumatoidarthritisraacasecontrolstudy AT xinjie roleofserumcartilageoligomericmatrixproteincompinthediagnosisofrheumatoidarthritisraacasecontrolstudy |