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The effects of corrective surgery on endothelial biomarkers and anthropometric data in children with congenital heart disease
OBJECTIVE: To investigate the influence of surgical correction on biomarkers of endothelial dysfunction in children with congenital heart disease and to evaluate anthropometric data. METHODS: Children with pulmonary hypertension (PH) or Tetralogy of Fallot (TOF) who were scheduled for corrective sur...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536639/ https://www.ncbi.nlm.nih.gov/pubmed/28415932 http://dx.doi.org/10.1177/0300060516685659 |
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author | Chung, Hung-Tao Chang, Yu-Sheng Liao, Sui-Ling Lai, Shen-Hao |
author_facet | Chung, Hung-Tao Chang, Yu-Sheng Liao, Sui-Ling Lai, Shen-Hao |
author_sort | Chung, Hung-Tao |
collection | PubMed |
description | OBJECTIVE: To investigate the influence of surgical correction on biomarkers of endothelial dysfunction in children with congenital heart disease and to evaluate anthropometric data. METHODS: Children with pulmonary hypertension (PH) or Tetralogy of Fallot (TOF) who were scheduled for corrective surgery were enrolled in this prospective study. Age-matched healthy children were included as controls. Demographic, haemodynamic and cardiac ultrasonography data were collected. Blood samples were taken pre-surgery, 24–48 hours post-surgery and again 3–6 months later. Several biomarkers (protein C, soluble platelet selectin [CD62P], soluble endothelium selectin [CD62E], soluble leukocyte selectin [CD62L], plasma von Willebrand Factor [vWF] atrial natriuretic peptide [ANP], brain natriuretic peptide[(BNP] and insulin-like growth factor-1 [IGF-1]) were measured. RESULTS: Sixty-three children (32 with PH, 15 with TOF, and 16 controls) were enrolled. No significant differences between the PH and TOF groups were observed in the expression of biomarkers pre- and post-surgery. IGF-1 levels were closely related to anthropometric data, particularly those children with PH. Expression of IGF-1 and weight/height normalized after corrective surgery. CONCLUSIONS: No significant endothelial dysfunction was observed in children with PH or TOF before or after corrective surgery. Significant retardation of growth, particularly weight, was found before surgery and may be related to IGF-1 suppression. |
format | Online Article Text |
id | pubmed-5536639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-55366392017-10-03 The effects of corrective surgery on endothelial biomarkers and anthropometric data in children with congenital heart disease Chung, Hung-Tao Chang, Yu-Sheng Liao, Sui-Ling Lai, Shen-Hao J Int Med Res Research Reports OBJECTIVE: To investigate the influence of surgical correction on biomarkers of endothelial dysfunction in children with congenital heart disease and to evaluate anthropometric data. METHODS: Children with pulmonary hypertension (PH) or Tetralogy of Fallot (TOF) who were scheduled for corrective surgery were enrolled in this prospective study. Age-matched healthy children were included as controls. Demographic, haemodynamic and cardiac ultrasonography data were collected. Blood samples were taken pre-surgery, 24–48 hours post-surgery and again 3–6 months later. Several biomarkers (protein C, soluble platelet selectin [CD62P], soluble endothelium selectin [CD62E], soluble leukocyte selectin [CD62L], plasma von Willebrand Factor [vWF] atrial natriuretic peptide [ANP], brain natriuretic peptide[(BNP] and insulin-like growth factor-1 [IGF-1]) were measured. RESULTS: Sixty-three children (32 with PH, 15 with TOF, and 16 controls) were enrolled. No significant differences between the PH and TOF groups were observed in the expression of biomarkers pre- and post-surgery. IGF-1 levels were closely related to anthropometric data, particularly those children with PH. Expression of IGF-1 and weight/height normalized after corrective surgery. CONCLUSIONS: No significant endothelial dysfunction was observed in children with PH or TOF before or after corrective surgery. Significant retardation of growth, particularly weight, was found before surgery and may be related to IGF-1 suppression. SAGE Publications 2017-03-06 2017-04 /pmc/articles/PMC5536639/ /pubmed/28415932 http://dx.doi.org/10.1177/0300060516685659 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Reports Chung, Hung-Tao Chang, Yu-Sheng Liao, Sui-Ling Lai, Shen-Hao The effects of corrective surgery on endothelial biomarkers and anthropometric data in children with congenital heart disease |
title | The effects of corrective surgery on endothelial biomarkers and anthropometric data in children with congenital heart disease |
title_full | The effects of corrective surgery on endothelial biomarkers and anthropometric data in children with congenital heart disease |
title_fullStr | The effects of corrective surgery on endothelial biomarkers and anthropometric data in children with congenital heart disease |
title_full_unstemmed | The effects of corrective surgery on endothelial biomarkers and anthropometric data in children with congenital heart disease |
title_short | The effects of corrective surgery on endothelial biomarkers and anthropometric data in children with congenital heart disease |
title_sort | effects of corrective surgery on endothelial biomarkers and anthropometric data in children with congenital heart disease |
topic | Research Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536639/ https://www.ncbi.nlm.nih.gov/pubmed/28415932 http://dx.doi.org/10.1177/0300060516685659 |
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