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Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes

OBJECTIVES: To evaluate fasting serum insulin levels and insulin resistance, and their association with blood rheology, in Japanese young adults without diabetes. METHODS: Blood samples were analysed and blood rheology was estimated using haematological parameters. Whole blood passage time was measu...

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Autores principales: Yoshida, Kensuke, Kimura, Takao, Aoki, Tomoyuki, Tsunekawa, Katsuhiko, Araki, Osamu, Shoho, Yoshifumi, Nara, Makoto, Sumino, Hiroyuki, Murakami, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536708/
https://www.ncbi.nlm.nih.gov/pubmed/26920928
http://dx.doi.org/10.1177/0300060515627561
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author Yoshida, Kensuke
Kimura, Takao
Aoki, Tomoyuki
Tsunekawa, Katsuhiko
Araki, Osamu
Shoho, Yoshifumi
Nara, Makoto
Sumino, Hiroyuki
Murakami, Masami
author_facet Yoshida, Kensuke
Kimura, Takao
Aoki, Tomoyuki
Tsunekawa, Katsuhiko
Araki, Osamu
Shoho, Yoshifumi
Nara, Makoto
Sumino, Hiroyuki
Murakami, Masami
author_sort Yoshida, Kensuke
collection PubMed
description OBJECTIVES: To evaluate fasting serum insulin levels and insulin resistance, and their association with blood rheology, in Japanese young adults without diabetes. METHODS: Blood samples were analysed and blood rheology was estimated using haematological parameters. Whole blood passage time was measured using a Hitachi MC-FAN(©) microchannel array flow analyser. RESULTS: Out of 151 subjects (mean age, 24.1 ± 1.5 years), fasting serum insulin levels and insulin resistance (using homeostasis model assessment-estimated insulin resistance [HOMA-IR]), were positively correlated with longer whole blood passage times and higher values for haematocrit (Hct), haemoglobin (Hb), fibrinogen, body weight, body mass index (BMI), triglycerides, and low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, and were negatively correlated with HDL-C. Whole blood passage time correlated with body weight, BMI, LDL-C/HDL-C ratio, Hct, Hb, white blood cell (WBC) count, platelet count, fibrinogen, fasting serum insulin levels, and HOMA-IR. Multiple regression analysis revealed that whole blood passage time was independently associated with Hct, fibrinogen levels, and WBC count. CONCLUSIONS: Fasting serum insulin levels and insulin resistance were associated with blood rheology, and may influence blood rheology by modulating haematological parameters and lipid parameters in young adults without diabetes.
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spelling pubmed-55367082017-10-03 Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes Yoshida, Kensuke Kimura, Takao Aoki, Tomoyuki Tsunekawa, Katsuhiko Araki, Osamu Shoho, Yoshifumi Nara, Makoto Sumino, Hiroyuki Murakami, Masami J Int Med Res Research Reports OBJECTIVES: To evaluate fasting serum insulin levels and insulin resistance, and their association with blood rheology, in Japanese young adults without diabetes. METHODS: Blood samples were analysed and blood rheology was estimated using haematological parameters. Whole blood passage time was measured using a Hitachi MC-FAN(©) microchannel array flow analyser. RESULTS: Out of 151 subjects (mean age, 24.1 ± 1.5 years), fasting serum insulin levels and insulin resistance (using homeostasis model assessment-estimated insulin resistance [HOMA-IR]), were positively correlated with longer whole blood passage times and higher values for haematocrit (Hct), haemoglobin (Hb), fibrinogen, body weight, body mass index (BMI), triglycerides, and low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, and were negatively correlated with HDL-C. Whole blood passage time correlated with body weight, BMI, LDL-C/HDL-C ratio, Hct, Hb, white blood cell (WBC) count, platelet count, fibrinogen, fasting serum insulin levels, and HOMA-IR. Multiple regression analysis revealed that whole blood passage time was independently associated with Hct, fibrinogen levels, and WBC count. CONCLUSIONS: Fasting serum insulin levels and insulin resistance were associated with blood rheology, and may influence blood rheology by modulating haematological parameters and lipid parameters in young adults without diabetes. SAGE Publications 2016-02-26 2016-06 /pmc/articles/PMC5536708/ /pubmed/26920928 http://dx.doi.org/10.1177/0300060515627561 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Reports
Yoshida, Kensuke
Kimura, Takao
Aoki, Tomoyuki
Tsunekawa, Katsuhiko
Araki, Osamu
Shoho, Yoshifumi
Nara, Makoto
Sumino, Hiroyuki
Murakami, Masami
Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes
title Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes
title_full Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes
title_fullStr Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes
title_full_unstemmed Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes
title_short Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes
title_sort fasting serum insulin levels and insulin resistance are associated with blood rheology in japanese young adults without diabetes
topic Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536708/
https://www.ncbi.nlm.nih.gov/pubmed/26920928
http://dx.doi.org/10.1177/0300060515627561
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