Cargando…

5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis

OBJECTIVE: We evaluated the efficacy of 5-HT3 receptor antagonists for the prevention of postoperative shivering. METHODS: We searched PubMed, the Cochrane Library, EMBASE and Web of Knowledge to find randomized controlled trials (RCT) of 5-HT3 receptor antagonists for the prevention of postoperativ...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Chengmao, Zhu, Yu, Liu, Zhen, Ruan, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536761/
https://www.ncbi.nlm.nih.gov/pubmed/27856931
http://dx.doi.org/10.1177/0300060516668776
Descripción
Sumario:OBJECTIVE: We evaluated the efficacy of 5-HT3 receptor antagonists for the prevention of postoperative shivering. METHODS: We searched PubMed, the Cochrane Library, EMBASE and Web of Knowledge to find randomized controlled trials (RCT) of 5-HT3 receptor antagonists for the prevention of postoperative shivering. Two researchers independently screened studies, extracted data, and assessed quality in accordance with the inclusion and exclusion criteria, and then conducted a meta-analysis using RevMan 5.2. RESULTS: Ultimately, 14 RCTs that included 980 patients were included in the analysis. We found that: 1) the incidence of shivering was significantly lower in 5-HT3 groups than placebo groups (relative risk, [RR] = 0.48, 95% confidence interval [CI] 0.40 – 0.58); 2) there was no significant difference in the incidence of shivering between 5-HT3 groups and meperidine groups (RR = 0.89, 95% CI 0.60 – 1.34). CONCLUSION: 5-HT3 receptor antagonists appear to prevent postoperative shivering, with a broadly comparable efficacy to meperidine.