Cargando…

5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis

OBJECTIVE: We evaluated the efficacy of 5-HT3 receptor antagonists for the prevention of postoperative shivering. METHODS: We searched PubMed, the Cochrane Library, EMBASE and Web of Knowledge to find randomized controlled trials (RCT) of 5-HT3 receptor antagonists for the prevention of postoperativ...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Chengmao, Zhu, Yu, Liu, Zhen, Ruan, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536761/
https://www.ncbi.nlm.nih.gov/pubmed/27856931
http://dx.doi.org/10.1177/0300060516668776
_version_ 1783254080141918208
author Zhou, Chengmao
Zhu, Yu
Liu, Zhen
Ruan, Lin
author_facet Zhou, Chengmao
Zhu, Yu
Liu, Zhen
Ruan, Lin
author_sort Zhou, Chengmao
collection PubMed
description OBJECTIVE: We evaluated the efficacy of 5-HT3 receptor antagonists for the prevention of postoperative shivering. METHODS: We searched PubMed, the Cochrane Library, EMBASE and Web of Knowledge to find randomized controlled trials (RCT) of 5-HT3 receptor antagonists for the prevention of postoperative shivering. Two researchers independently screened studies, extracted data, and assessed quality in accordance with the inclusion and exclusion criteria, and then conducted a meta-analysis using RevMan 5.2. RESULTS: Ultimately, 14 RCTs that included 980 patients were included in the analysis. We found that: 1) the incidence of shivering was significantly lower in 5-HT3 groups than placebo groups (relative risk, [RR] = 0.48, 95% confidence interval [CI] 0.40 – 0.58); 2) there was no significant difference in the incidence of shivering between 5-HT3 groups and meperidine groups (RR = 0.89, 95% CI 0.60 – 1.34). CONCLUSION: 5-HT3 receptor antagonists appear to prevent postoperative shivering, with a broadly comparable efficacy to meperidine.
format Online
Article
Text
id pubmed-5536761
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-55367612017-10-03 5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis Zhou, Chengmao Zhu, Yu Liu, Zhen Ruan, Lin J Int Med Res Meta-Analysis OBJECTIVE: We evaluated the efficacy of 5-HT3 receptor antagonists for the prevention of postoperative shivering. METHODS: We searched PubMed, the Cochrane Library, EMBASE and Web of Knowledge to find randomized controlled trials (RCT) of 5-HT3 receptor antagonists for the prevention of postoperative shivering. Two researchers independently screened studies, extracted data, and assessed quality in accordance with the inclusion and exclusion criteria, and then conducted a meta-analysis using RevMan 5.2. RESULTS: Ultimately, 14 RCTs that included 980 patients were included in the analysis. We found that: 1) the incidence of shivering was significantly lower in 5-HT3 groups than placebo groups (relative risk, [RR] = 0.48, 95% confidence interval [CI] 0.40 – 0.58); 2) there was no significant difference in the incidence of shivering between 5-HT3 groups and meperidine groups (RR = 0.89, 95% CI 0.60 – 1.34). CONCLUSION: 5-HT3 receptor antagonists appear to prevent postoperative shivering, with a broadly comparable efficacy to meperidine. SAGE Publications 2016-11-17 2016-12 /pmc/articles/PMC5536761/ /pubmed/27856931 http://dx.doi.org/10.1177/0300060516668776 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Meta-Analysis
Zhou, Chengmao
Zhu, Yu
Liu, Zhen
Ruan, Lin
5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis
title 5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis
title_full 5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis
title_fullStr 5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis
title_full_unstemmed 5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis
title_short 5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis
title_sort 5-ht3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536761/
https://www.ncbi.nlm.nih.gov/pubmed/27856931
http://dx.doi.org/10.1177/0300060516668776
work_keys_str_mv AT zhouchengmao 5ht3receptorantagonistsforthepreventionofpostoperativeshiveringametaanalysis
AT zhuyu 5ht3receptorantagonistsforthepreventionofpostoperativeshiveringametaanalysis
AT liuzhen 5ht3receptorantagonistsforthepreventionofpostoperativeshiveringametaanalysis
AT ruanlin 5ht3receptorantagonistsforthepreventionofpostoperativeshiveringametaanalysis