Clinical features and biological markers of lung cancer-associated stroke

OBJECTIVE: To identify the unique clinical features and biological markers of lung cancer-associated stroke. METHODS: We recruited 102 patients with lung cancer plus stroke, 102 with lung cancer, and 102 with stroke. Detailed information was analysed and compared among groups. RESULTS: The groups we...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Xingrui, Chen, Li, Zeng, Jinsheng, Qin, Chao, Cheng, Daobin, Wei, Xinxian, Liang, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536770/
https://www.ncbi.nlm.nih.gov/pubmed/28322105
http://dx.doi.org/10.1177/0300060516666398
_version_ 1783254082255847424
author Xie, Xingrui
Chen, Li
Zeng, Jinsheng
Qin, Chao
Cheng, Daobin
Wei, Xinxian
Liang, Zhijian
author_facet Xie, Xingrui
Chen, Li
Zeng, Jinsheng
Qin, Chao
Cheng, Daobin
Wei, Xinxian
Liang, Zhijian
author_sort Xie, Xingrui
collection PubMed
description OBJECTIVE: To identify the unique clinical features and biological markers of lung cancer-associated stroke. METHODS: We recruited 102 patients with lung cancer plus stroke, 102 with lung cancer, and 102 with stroke. Detailed information was analysed and compared among groups. RESULTS: The groups were age-matched. Patients with lung cancer plus stroke showed multiple lesions involving multiple cerebral artery territories on magnetic resonance imaging, compared with stroke-alone patients. These patients also had a poorer modified Rankin Scale score at 30 days, and high mortality (18.6%). Patients with lung cancer plus stroke had a higher incidence of metastasis, and higher blood levels of D-dimer, CA125 and CA199 compared with patients with lung cancer alone. Multivariate logistic regression analysis showed that levels of D-dimer, CA125 and CA199 were independently related to lung cancer-associated stroke. CONCLUSION: Elevated plasma D-dimer, CA125 and CA199 may be independent risk factors for and biomarkers of lung cancer-associated stroke.
format Online
Article
Text
id pubmed-5536770
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-55367702017-10-03 Clinical features and biological markers of lung cancer-associated stroke Xie, Xingrui Chen, Li Zeng, Jinsheng Qin, Chao Cheng, Daobin Wei, Xinxian Liang, Zhijian J Int Med Res Clinical Reports OBJECTIVE: To identify the unique clinical features and biological markers of lung cancer-associated stroke. METHODS: We recruited 102 patients with lung cancer plus stroke, 102 with lung cancer, and 102 with stroke. Detailed information was analysed and compared among groups. RESULTS: The groups were age-matched. Patients with lung cancer plus stroke showed multiple lesions involving multiple cerebral artery territories on magnetic resonance imaging, compared with stroke-alone patients. These patients also had a poorer modified Rankin Scale score at 30 days, and high mortality (18.6%). Patients with lung cancer plus stroke had a higher incidence of metastasis, and higher blood levels of D-dimer, CA125 and CA199 compared with patients with lung cancer alone. Multivariate logistic regression analysis showed that levels of D-dimer, CA125 and CA199 were independently related to lung cancer-associated stroke. CONCLUSION: Elevated plasma D-dimer, CA125 and CA199 may be independent risk factors for and biomarkers of lung cancer-associated stroke. SAGE Publications 2016-11-07 2016-12 /pmc/articles/PMC5536770/ /pubmed/28322105 http://dx.doi.org/10.1177/0300060516666398 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Reports
Xie, Xingrui
Chen, Li
Zeng, Jinsheng
Qin, Chao
Cheng, Daobin
Wei, Xinxian
Liang, Zhijian
Clinical features and biological markers of lung cancer-associated stroke
title Clinical features and biological markers of lung cancer-associated stroke
title_full Clinical features and biological markers of lung cancer-associated stroke
title_fullStr Clinical features and biological markers of lung cancer-associated stroke
title_full_unstemmed Clinical features and biological markers of lung cancer-associated stroke
title_short Clinical features and biological markers of lung cancer-associated stroke
title_sort clinical features and biological markers of lung cancer-associated stroke
topic Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536770/
https://www.ncbi.nlm.nih.gov/pubmed/28322105
http://dx.doi.org/10.1177/0300060516666398
work_keys_str_mv AT xiexingrui clinicalfeaturesandbiologicalmarkersoflungcancerassociatedstroke
AT chenli clinicalfeaturesandbiologicalmarkersoflungcancerassociatedstroke
AT zengjinsheng clinicalfeaturesandbiologicalmarkersoflungcancerassociatedstroke
AT qinchao clinicalfeaturesandbiologicalmarkersoflungcancerassociatedstroke
AT chengdaobin clinicalfeaturesandbiologicalmarkersoflungcancerassociatedstroke
AT weixinxian clinicalfeaturesandbiologicalmarkersoflungcancerassociatedstroke
AT liangzhijian clinicalfeaturesandbiologicalmarkersoflungcancerassociatedstroke

Ejemplares similares