Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection

Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation...

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Detalles Bibliográficos
Autores principales: Sheela, Sheenu, Ito, Sawa, Strich, Jeffrey R., Manion, Maura, Montemayor-Garcia, Celina, Wang, Hao-Wei, Oetjen, Karolyn A., West, Kamile A., Barrett, Austin J., Parta, Mark, Gea-Banacloche, Juan, Holland, Steven M., Hourigan, Christopher S., Lai, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536877/
https://www.ncbi.nlm.nih.gov/pubmed/28794968
http://dx.doi.org/10.1016/j.lrr.2017.07.001
Descripción
Sumario:Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). There is no consensus regarding management of invasive disseminated Fusarium infections in the setting of prolonged neutropenia (Tortorano et al., 2014) [1]. We report a case of disseminated Fusarium in a patient with relapsed AML who underwent successful chemotherapy and haplo-identical allogeneic SCT with administration of granulocyte colony stimulating factor (G-CSF) and granulocyte infusions.

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