Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

The mechanosensing ability of lymphocytes regulates their activation in response to antigen stimulation, but the underlying mechanism remains unexplored. Here, we report that B cell mechanosensing-governed activation requires BCR signaling molecules. PMA-induced activation of PKCβ can bypass the Btk...

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Detalles Bibliográficos
Autores principales: Shaheen, Samina, Wan, Zhengpeng, Li, Zongyu, Chau, Alicia, Li, Xinxin, Zhang, Shaosen, Liu, Yang, Yi, Junyang, Zeng, Yingyue, Wang, Jing, Chen, Xiangjun, Xu, Liling, Chen, Wei, Wang, Fei, Lu, Yun, Zheng, Wenjie, Shi, Yan, Sun, Xiaolin, Li, Zhanguo, Xiong, Chunyang, Liu, Wanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536945/
https://www.ncbi.nlm.nih.gov/pubmed/28755662
http://dx.doi.org/10.7554/eLife.23060

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